MolNFT v1 · #270471 · protein

AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-36 specific (O88491)

O88491: “AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-36 specific (O88491)”. 16 pockets (best druggability 0.76). MolNFT v1 #270471 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: O88491
Type: protein
Length: 2,588 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xB44F19a0cb161828322eEEd13F55d4C3C34938d2
Molecule: Histone-lysine N-methyltransferase, H3 lysine-36 specific
UniProt: O88491
Pockets: 16 · best druggability 0.76

Structure

1 distinct chain · 6% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histone-lysine N-methyltransferase, H3 lysine-36 specific	protein	2588	6% helix, 5% strand	O88491

Pockets

16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	650	0.76	0.81	47	empty
2	1024	0.74	0.77	82	empty
3	717	0.72	0.78	70	empty
4	85	0.51	0.84	18	empty
5	206	0.50	0.75	20	empty

Compared structures

2NAA · NSD1-PHD_5-C5HCH tandem domain structure · an experimental structure of the same protein · chain A against A, TM-score 0.04
2NAA · NSD1-PHD_5-C5HCH tandem domain structure · an experimental structure of the same protein · chain A against A, TM-score 0.04

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O88491
Elsewhere: UniProt O88491 · AlphaFold DB O88491

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