MolNFT v1 · #267924 · protein
AlphaFold monomer V2.0 prediction for npc intracellular cholesterol transporter 1 (O35604)
O35604: “AlphaFold monomer V2.0 prediction for npc intracellular cholesterol transporter 1 (O35604)”. 12 pockets (best druggability 0.85). MolNFT v1 #267924 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O35604
- Type
- protein
- Length
- 1,277 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xedc07A86dE46108e804E3E81e5b0cAF1692Cf5cF
- Molecule
- Npc intracellular cholesterol transporter 1
- UniProt
- O35604
- Pockets
- 12 · best druggability 0.85
Structure
1 distinct chain · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Npc intracellular cholesterol transporter 1 | protein | 1277 | 53% helix, 12% strand | O35604 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1148 | 0.85 | 0.86 | 91 | empty |
| 2 | 1140 | 0.83 | 0.84 | 121 | empty |
| 3 | 521 | 0.80 | 0.86 | 53 | empty |
| 4 | 685 | 0.78 | 0.83 | 47 | empty |
| 5 | 906 | 0.74 | 0.78 | 75 | empty |
Modifications
Observed in the structure: 15 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35604
- Elsewhere: UniProt O35604 · AlphaFold DB O35604
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