MolNFT v1 · #264905 · protein

AlphaFold monomer V2.0 prediction for nicastrin (Q8CGU6)

Q8CGU6: “AlphaFold monomer V2.0 prediction for nicastrin (Q8CGU6)”. 9 pockets (best druggability 0.51). MolNFT v1 #264905 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q8CGU6
Type: protein
Length: 708 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x40B9C9d5F084D34d026E9d5Dd10501AcdF6d6152
Molecule: Nicastrin
UniProt: Q8CGU6
Pockets: 9 · best druggability 0.51

Structure

1 distinct chain · 37% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nicastrin	protein	708	37% helix, 18% strand	Q8CGU6

Pockets

9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	228	0.51	0.76	25	empty
2	55	0.37	0.80	14	empty
3	111	0.37	0.74	17	empty
4	58	0.36	0.79	18	empty
5	80	0.35	0.76	18	empty

Modifications

Observed in the structure: 5 disulfide (disulfide).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8CGU6
Elsewhere: UniProt Q8CGU6 · AlphaFold DB Q8CGU6

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