MolNFT v1 · #264898 · protein

AlphaFold monomer V2.0 prediction for nicastrin (Q54JT7)

Q54JT7: “AlphaFold monomer V2.0 prediction for nicastrin (Q54JT7)”. 7 pockets (best druggability 0.55). MolNFT v1 #264898 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q54JT7
Type: protein
Length: 659 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xF41644f9d22c5EB7536Cde74EF3Cc4f1AC48928e
Molecule: Nicastrin
UniProt: Q54JT7
Pockets: 7 · best druggability 0.55

Structure

1 distinct chain · 35% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nicastrin	protein	659	35% helix, 23% strand	Q54JT7

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	325	0.55	0.75	30	empty
2	199	0.53	0.78	23	empty
3	211	0.51	0.76	32	empty
4	140	0.46	0.77	20	empty
5	77	0.40	0.78	22	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q54JT7
Elsewhere: UniProt Q54JT7 · AlphaFold DB Q54JT7

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