MolNFT v1 · #263026 · protein

AlphaFold monomer V2.0 prediction for protein kinase C-binding protein NELL2 (Q99435)

Q99435: “AlphaFold monomer V2.0 prediction for protein kinase C-binding protein NELL2 (Q99435)”. 6 pockets (best druggability 0.63). MolNFT v1 #263026 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q99435
Type: protein
Length: 816 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x40B9C9d5F084D34d026E9d5Dd10501AcdF6d6152
Molecule: Protein kinase C-binding protein NELL2
UniProt: Q99435
Pockets: 6 · best druggability 0.63

Structure

1 distinct chain · 11% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein kinase C-binding protein NELL2	protein	816	11% helix, 38% strand	Q99435

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	590	0.63	0.75	59	empty
2	189	0.44	0.74	24	empty
3	70	0.39	0.78	24	empty
4	70	0.37	0.78	20	empty
5	86	0.36	0.75	15	empty

Modifications

Observed in the structure: 42 disulfide (disulfide).

Compared structures

6POG · Crystal structure of the NELL2 EGF1-6-ROBO3 FN1 complex · an experimental structure of the same protein · chain A against B, TM-score 0.16
6POG · Crystal structure of the NELL2 EGF1-6-Robo3 FN1 complex · an experimental structure of the same protein · chain A against B, TM-score 0.16

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99435
Elsewhere: UniProt Q99435 · AlphaFold DB Q99435

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