MolNFT v1 · #260513 · protein

AlphaFold monomer V2.0 prediction for nucleoporin NDC1 (Q9BTX1)

Q9BTX1: “AlphaFold monomer V2.0 prediction for nucleoporin NDC1 (Q9BTX1)”. 4 pockets (best druggability 0.64). MolNFT v1 #260513 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: Q9BTX1
Type: protein
Length: 674 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x8a472F9414Bedc654E6640D356517d0b0Ec25226
Molecule: Nucleoporin NDC1
UniProt: Q9BTX1
Pockets: 4 · best druggability 0.64

Structure

1 distinct chain · 59% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NDC1	protein	674	59% helix, 2% strand	Q9BTX1

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	414	0.64	0.78	43	empty
2	87	0.55	0.85	23	empty
3	85	0.43	0.78	16	empty
4	124	0.38	0.73	21	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7R5J · Human nuclear pore complex (dilated) · an experimental structure of the same protein · chain A against E1, TM-score 0.80
7R5K · Human nuclear pore complex (constricted) · an experimental structure of the same protein · chain A against E1, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BTX1
Elsewhere: UniProt Q9BTX1 · AlphaFold DB Q9BTX1

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