MolNFT v1 · #250966 · protein
AlphaFold monomer V2.0 prediction for udp-N-acetylmuramate--L-alanine ligase (P45066)
P45066: “AlphaFold monomer V2.0 prediction for udp-N-acetylmuramate--L-alanine ligase (P45066)”. 4 pockets (best druggability 0.63). MolNFT v1 #250966 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P45066
- Type
- protein
- Length
- 475 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7012c0b45c68a2c067644b9d3e5DDa06892c6957
- Molecule
- Udp-N-acetylmuramate--L-alanine ligase
- UniProt
- P45066
- Pockets
- 4 · best druggability 0.63
Structure
1 distinct chain · 39% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Udp-N-acetylmuramate--L-alanine ligase | protein | 475 | 39% helix, 25% strand | P45066 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.63 | 0.82 | 30 | empty |
| 2 | 442 | 0.63 | 0.77 | 43 | empty |
| 3 | 88 | 0.53 | 0.84 | 23 | empty |
| 4 | 66 | 0.32 | 0.76 | 14 | empty |
Compared structures
- 1GQY · Murc - crystal structure of the enzyme from haemophilus influenzae complexed with amppcp · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 1GQY · Murc - crystal structure of the enzyme from haemophilus influenzae complexed with amppcp · an experimental structure of the same protein · chain A against A, TM-score 0.97
- 1P31 · Crystal structure of udp-N-acetylmuramic ACID:L-alanine ligase (murc) from haemophilus… · an experimental structure of the same protein · chain A against B, TM-score 0.95
- 1P31 · Crystal Structure of UDP-N-acetylmuramic acid:L-alanine Ligase (MurC) from Haemophilus… · an experimental structure of the same protein · chain A against B, TM-score 0.95
- 1P3D · Crystal Structure of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) in Complex with UMA… · an experimental structure of the same protein · chain A against A, TM-score 0.95
- 1P3D · Crystal structure of udp-N-acetylmuramic ACID:L-alanine ligase (murc) in complex with uma… · an experimental structure of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45066
- Elsewhere: UniProt P45066 · AlphaFold DB P45066
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