MolNFT v1 · #248827 · protein
AlphaFold monomer V2.0 prediction for melatonin receptor type 1A (P48039)
P48039: “AlphaFold monomer V2.0 prediction for melatonin receptor type 1A (P48039)”. 5 pockets (best druggability 0.84). MolNFT v1 #248827 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P48039
- Type
- protein
- Length
- 350 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9B800d48d871ED865b4dc8330EC3e1EAD024B41F
- Molecule
- Melatonin receptor type 1A
- UniProt
- P48039
- Pockets
- 5 · best druggability 0.84
Structure
1 distinct chain · 73% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Melatonin receptor type 1A | protein | 350 | 73% helix, 2% strand | P48039 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.84 | 0.97 | 35 | empty |
| 2 | 96 | 0.44 | 0.79 | 17 | empty |
| 3 | 56 | 0.41 | 0.81 | 17 | empty |
| 4 | 95 | 0.41 | 0.77 | 15 | empty |
| 5 | 81 | 0.35 | 0.75 | 12 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6ME2 · Xfel crystal structure of human melatonin receptor MT1 in complex with ramelteon · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ME2 · XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ME5 · XFEL crystal structure of human melatonin receptor MT1 in complex with agomelatine · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ME5 · Xfel crystal structure of human melatonin receptor MT1 in complex with agomelatine · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6PS8 · XFEL MT1R structure by ligand exchange from agomelatine to 2-phenylmelatonin. · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6PS8 · Xfel MT1R structure by ligand exchange from agomelatine to 2- phenylmelatonin. · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ME4 · Xfel crystal structure of human melatonin receptor MT1 in complex with 2-iodomelatonin · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ME4 · XFEL crystal structure of human melatonin receptor MT1 in complex with 2-iodomelatonin · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ME3 · XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ME3 · Xfel crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 7VGZ · MT1-remalteon-Gi complex · an experimental structure of the same protein · chain A against B, TM-score 0.76
- 7VGZ · MT1-remalteon-gi complex · an experimental structure of the same protein · chain A against B, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48039
- Elsewhere: UniProt P48039 · AlphaFold DB P48039
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