MolNFT v1 · #245026 · protein
AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MSH3 (P20585)
P20585: “AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MSH3 (P20585)”. 11 pockets (best druggability 0.77). MolNFT v1 #245026 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P20585
- Type
- protein
- Length
- 1,137 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xa0Ce8C82aCdfDBeDc93F6adD397ac7f37Ed28C7a
- Molecule
- DNA mismatch repair protein MSH3
- UniProt
- P20585
- Pockets
- 11 · best druggability 0.77
Structure
1 distinct chain · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA mismatch repair protein MSH3 | protein | 1137 | 40% helix, 15% strand | P20585 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 826 | 0.77 | 0.81 | 82 | empty |
| 2 | 706 | 0.74 | 0.80 | 72 | empty |
| 3 | 679 | 0.68 | 0.76 | 54 | empty |
| 4 | 85 | 0.67 | 0.92 | 21 | empty |
| 5 | 69 | 0.42 | 0.81 | 20 | empty |
Compared structures
- 8R7C · MutSbeta bound to compound CHDI-00915542 in the canonical DNA-mismatch bound form · an experimental structure of the same protein · chain A against F, TM-score 0.76
- 8R7E · MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 8OLX · MutSbeta bound to (CAG)2 DNA (canonical form) · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 8R7V · MutSbeta bound to compound CHDI-00898647 in the canonical DNA-mismatch bound form · an experimental structure of the same protein · chain A against B, TM-score 0.72
- 8RZ7 · (CAG)2 DNA-bound MutSbeta in open form with kinked MSH2 clamp · an experimental structure of the same protein · chain A against B, TM-score 0.69
- 8OM9 · MutSbeta bound to (CAG)2 DNA (open form) · an experimental structure of the same protein · chain A against B, TM-score 0.68
- 8OM5 · DNA-free open form of MutSbeta · an experimental structure of the same protein · chain A against B, TM-score 0.67
- 8OMQ · DNA-unbound MutSbeta-ATP complex (straight clamp form) · an experimental structure of the same protein · chain A against B, TM-score 0.48
- 8OMO · DNA-unbound MutSbeta-ATP complex (bent clamp form) · an experimental structure of the same protein · chain A against B, TM-score 0.47
- 8OMA · MutSbeta bound to 61bp homoduplex DNA · an experimental structure of the same protein · chain A against B, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20585
- Elsewhere: UniProt P20585 · AlphaFold DB P20585
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.