MolNFT v1 · #244493 · protein
AlphaFold monomer V2.0 prediction for ATP-dependent lipid a-core flippase (P63359)
P63359: “AlphaFold monomer V2.0 prediction for ATP-dependent lipid a-core flippase (P63359)”. 6 pockets (best druggability 0.62). MolNFT v1 #244493 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P63359
- Type
- protein
- Length
- 582 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB4A37162249b8bb2099dCDA2B73160a0D5000650
- Molecule
- ATP-dependent lipid a-core flippase
- UniProt
- P63359
- Pockets
- 6 · best druggability 0.62
Structure
1 distinct chain · 66% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent lipid a-core flippase | protein | 582 | 66% helix, 10% strand | P63359 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.62 | 0.90 | 15 | empty |
| 2 | 419 | 0.61 | 0.76 | 35 | empty |
| 3 | 113 | 0.54 | 0.82 | 19 | empty |
| 4 | 156 | 0.43 | 0.75 | 26 | empty |
| 5 | 121 | 0.43 | 0.77 | 22 | empty |
Compared structures
- 6BL6 · Crystallization of lipid A transporter MsbA from Salmonella typhimurium · an experimental structure of the same protein · chain A against B, TM-score 0.82
- 6BL6 · Crystallization of lipid a transporter msba from salmonella typhimurium · an experimental structure of the same protein · chain A against A, TM-score 0.82
- 3B5Y · Crystal structure of msba from salmonella typhimurium with amppnp · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 3B5Y · Crystal Structure of MsbA from Salmonella typhimurium with AMPPNP · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 3B5Z · Crystal Structure of MsbA from Salmonella typhimurium with ADP Vanadate · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 3B5Z · Crystal structure of msba from salmonella typhimurium with ADP vanadate · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 3B60 · Crystal Structure of MsbA from Salmonella typhimurium with AMPPNP, higher resolution form · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 3B60 · Crystal structure of msba from salmonella typhimurium with amppnp, higher resolution form · an experimental structure of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63359
- Elsewhere: UniProt P63359 · AlphaFold DB P63359
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