MolNFT v1 · #242210 · protein
AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 4 (Q39024)
Q39024: “AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 4 (Q39024)”. 5 pockets (best druggability 0.71). MolNFT v1 #242210 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q39024
- Type
- protein
- Length
- 376 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x0a518D7f85eD490B16cdD47CeC359Ccb050F802E
- Molecule
- Mitogen-activated protein kinase 4
- UniProt
- Q39024
- Pockets
- 5 · best druggability 0.71
Structure
1 distinct chain · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 4 | protein | 376 | 39% helix, 17% strand | Q39024 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 394 | 0.71 | 0.83 | 37 | empty |
| 2 | 114 | 0.59 | 0.85 | 16 | empty |
| 3 | 105 | 0.45 | 0.79 | 16 | empty |
| 4 | 57 | 0.39 | 0.80 | 18 | empty |
| 5 | 58 | 0.34 | 0.77 | 14 | empty |
Compared structures
- 7W5C · Crystal structure of Mitogen Activated Protein Kinase 4 (MPK4) from Arabidopsis thaliana · an experimental structure of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q39024
- Elsewhere: UniProt Q39024 · AlphaFold DB Q39024
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