MolNFT v1 · #231021 · protein
AlphaFold monomer V2.0 prediction for 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (P57703)
P57703: “AlphaFold monomer V2.0 prediction for 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase…”. 9 pockets (best druggability 0.78). MolNFT v1 #231021 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P57703
- Type
- protein
- Length
- 766 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB35df660264f41795De49C83276C108A4ba91ADE
- Molecule
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- UniProt
- P57703
- Pockets
- 9 · best druggability 0.78
Structure
1 distinct chain · 47% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | protein | 766 | 47% helix, 14% strand | P57703 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 498 | 0.78 | 0.85 | 68 | empty |
| 2 | 69 | 0.75 | 0.99 | 19 | empty |
| 3 | 613 | 0.73 | 0.80 | 65 | empty |
| 4 | 406 | 0.72 | 0.83 | 39 | empty |
| 5 | 122 | 0.48 | 0.79 | 23 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P57703
- Elsewhere: UniProt P57703 · AlphaFold DB P57703
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