MolNFT v1 · #174771 · protein
AlphaFold monomer V2.0 prediction for 3-hydroxy-3-methylglutaryl- coenzyme a reductase (Q01237)
Q01237 · 3-hydroxy-3-methylglutaryl-coenzyme a reductase: “AlphaFold monomer V2.0 prediction for 3-hydroxy-3-methylglutaryl- coenzyme a reductase (Q01237)”. 6 pockets (best druggability 0.63). MolNFT v1 #174771 on GenesisL1: 3D structure…
- Accession
- Q01237
- Type
- protein
- Length
- 887 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5BeA89782341f98147F2D811B063F91F0aE7D7bF
- Molecule
- 3-hydroxy-3-methylglutaryl-coenzyme a reductase
- UniProt
- Q01237
- Pockets
- 6 · best druggability 0.63
Structure
1 distinct chain · 52% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-hydroxy-3-methylglutaryl-coenzyme a reductase | protein | 887 | 52% helix, 10% strand | Q01237 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 563 | 0.63 | 0.75 | 47 | empty |
| 2 | 229 | 0.54 | 0.77 | 29 | empty |
| 3 | 256 | 0.50 | 0.74 | 23 | empty |
| 4 | 248 | 0.50 | 0.74 | 43 | empty |
| 5 | 76 | 0.41 | 0.80 | 17 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01237
- Elsewhere: UniProt Q01237 · AlphaFold DB Q01237
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