UniProt X6RFN3
E3 ubiquitin-protein ligase RING2,Polycomb complex protein BMI-1 chimera (X6RFN3)
E3 ubiquitin-protein ligase RING2,Polycomb complex protein BMI-1 chimera (UniProt X6RFN3), EC 5.-.-.-: 4 experimental structures on GenesisL1, 1 ligand bound, 5 pockets. Binding sites, pockets, druggability and 3D structures in…
- UniProt
- X6RFN3
- Protein
- E3 ubiquitin-protein ligase RING2,Polycomb complex protein BMI-1 chimera
- EC
- 5.-.-.-
- Experimental structures
- 4
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
4 records of X6RFN3 in the MolNFT archive: 4 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6WI7 | RING1B-BMI1 fusion in closed conformation | x-ray diffraction | A | ZN | 1 (best 0.38) |
| 6WI7 | RING1B-BMI1 fusion in closed conformation | x-ray diffraction | A | ZN | — |
| 6WI8 | Inhibitor compound-induced confrontational change in Ring1b-Bmi1 domain structure | x-ray diffraction | A, B | ZN | 4 (best 0.73) |
| 6WI8 | Inhibitor compound-induced confrontational change in RING1B-BMI1 domain structure | x-ray diffraction | A, B | ZN | — |
Ligands
- ZN · Zinc ion · in 4 records
Experiment against prediction
- 6WI8 chain B against the predicted model P35226: TM-score 0.50, RMSD 1.47 Å
- 6WI8 chain B against the predicted model P35226: TM-score 0.50, RMSD 1.47 Å
- 6WI8 chain A against the predicted model P35226: TM-score 0.50, RMSD 1.05 Å
- 6WI8 chain A against the predicted model P35226: TM-score 0.50, RMSD 1.05 Å
- 6WI7 chain A against the predicted model P35226: TM-score 0.49, RMSD 1.23 Å
- 6WI7 chain A against the predicted model P35226: TM-score 0.49, RMSD 1.23 Å
Elsewhere
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