UniProt U2UMQ6
CRISPR-associated endonuclease Cas12a (U2UMQ6)
CRISPR-associated endonuclease Cas12a (UniProt U2UMQ6), EC 3.1.-.-, 3.1.21.1: 16 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 210 pockets. Binding sites, druggability and experiment against…
- UniProt
- U2UMQ6
- Protein
- CRISPR-associated endonuclease Cas12a
- EC
- 3.1.-.-, 3.1.21.1, 4.6.1.22
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 210 · 11 records with a druggable one
Structures
17 records of U2UMQ6 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5B43 | Crystal structure of acidaminococcus sp. CPF1 in complex with crrna and target DNA | x-ray diffraction | A | — | — |
| 5KK5 | AsCpf1(E993A)-crRNA-DNA ternary complex | x-ray diffraction | A | — | — |
| 5KK5 | ASCPF1(E993A)-crrna-DNA ternary complex | x-ray diffraction | A | — | — |
| 5XH6 | Crystal structure of the Acidaminococcus sp. BV3L6 Cpf1 RVR variant in complex with crRNA and… | x-ray diffraction | A | NA, CL | 20 (best 0.82) |
| 5XH6 | Crystal structure of the acidaminococcus sp. BV3L6 CPF1 rvr variant in complex with crrna and… | x-ray diffraction | A | NA, CL | — |
| 5XH7 | Crystal structure of the Acidaminococcus sp. BV3L6 Cpf1 RR variant in complex with crRNA and target… | x-ray diffraction | A | NA, CL | 19 (best 0.82) |
| 5XH7 | Crystal structure of the acidaminococcus sp. BV3L6 CPF1 rr variant in complex with crrna and target… | x-ray diffraction | A | NA, CL | — |
| 8SFH | WT CRISPR-Cas12a with a 5bp R-loop | electron microscopy | A | — | 20 (best 0.78) |
| 8SFI | WT CRISPR-Cas12a with a 8bp R-loop | electron microscopy | A | — | 16 (best 0.78) |
| 8SFJ | WT CRISPR-Cas12a with a 10bp R-loop | electron microscopy | A | — | 17 (best 0.80) |
| 8SFL | WT CRISPR-Cas12a with a 15bp R-loop | electron microscopy | A | — | 20 (best 0.82) |
| 8SFN | WT CRISPR-Cas12a with a 16bp R-loop and nontarget strand in the RuvC active site. | electron microscopy | A | — | 20 (best 0.82) |
| 8SFO | WT CRISPR-Cas12a with a 20bp R-loop and nontarget strand in the RuvC active site. | electron microscopy | A | MG | 20 (best 0.84) |
| 8SFP | WT CRISPR-Cas12a with the target strand in the RuvC active site. | electron microscopy | A | — | 20 (best 0.81) |
| 8SFQ | WT CRISPR-Cas12a post nontarget strand-cleavage with the the RuvC active site exposed. | electron microscopy | A | — | 18 (best 0.80) |
| 8SFR | WT CRISPR-Cas12a post nontarget strand cleavage. | electron microscopy | A | — | 20 (best 0.80) |
| U2UMQ6 | AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS12A (U2UMQ6) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5XH6 chain A against the predicted model U2UMQ6: TM-score 1.00, RMSD 0.66 Å
- 5XH6 chain A against the predicted model U2UMQ6: TM-score 1.00, RMSD 0.66 Å
- 5B43 chain A against the predicted model U2UMQ6: TM-score 1.00, RMSD 0.68 Å
- 5XH7 chain A against the predicted model U2UMQ6: TM-score 1.00, RMSD 0.71 Å
- 5XH7 chain A against the predicted model U2UMQ6: TM-score 1.00, RMSD 0.71 Å
- 8SFQ chain A against the predicted model U2UMQ6: TM-score 0.99, RMSD 1.36 Å
- 8SFO chain A against the predicted model U2UMQ6: TM-score 0.98, RMSD 1.48 Å
- 5KK5 chain A against the predicted model U2UMQ6: TM-score 0.98, RMSD 1.50 Å
- 5KK5 chain A against the predicted model U2UMQ6: TM-score 0.98, RMSD 1.50 Å
- 8SFP chain A against the predicted model U2UMQ6: TM-score 0.98, RMSD 1.59 Å
Elsewhere
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