UniProt S8G8I1
Prolyl-tRNA synthetase (ProRS) (S8G8I1)
Prolyl-tRNA synthetase (ProRS) (UniProt S8G8I1), EC 6.1.1.15: 15 experimental structures on GenesisL1, 10 ligands bound, 107 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- S8G8I1
- Protein
- Prolyl-tRNA synthetase (ProRS)
- EC
- 6.1.1.15
- Experimental structures
- 15
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 107 · 6 records with a druggable one
Structures
15 records of S8G8I1 in the MolNFT archive: 15 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5XIF | Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Toxoplasma gondii | x-ray diffraction | A, B | CL | 10 (best 0.85) |
| 5XIF | Crystal structure of prolyl-tRNA synthetase (prs) from toxoplasma gondii | x-ray diffraction | A, B | CL | — |
| 5XIG | Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1 | x-ray diffraction | A, B, C, D | ANP, MG, 87F | 20 (best 0.84) |
| 5XIG | Crystal structure of toxoplasma gondii prolyl-tRNA synthetase (tgprs) in complex with inhibitor 1 | x-ray diffraction | A, B, C, D | ANP, MG, 87F | — |
| 5XIH | Crystal structure of toxoplasma gondii prolyl-tRNA synthetase (tgprs) in complex with inhibitor 5 | x-ray diffraction | A, B, C, D | ANP, MG, 86U, CL | — |
| 5XII | Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 6 | x-ray diffraction | A, B, C, D | ANP, MG, 86X, CL | 19 (best 0.83) |
| 5XII | Crystal structure of toxoplasma gondii prolyl-tRNA synthetase (tgprs) in complex with inhibitor 6 | x-ray diffraction | A, B, C, D | ANP, MG, 86X, CL | — |
| 5XIJ | Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 9 | x-ray diffraction | A, B, C, D | ANP, MG, 873 | 18 (best 0.83) |
| 5XIJ | Crystal structure of toxoplasma gondii prolyl-tRNA synthetase (tgprs) in complex with inhibitor 9 | x-ray diffraction | A, B, C, D | ANP, MG, 873 | — |
| 5XIK | Crystal structure of toxoplasma gondii prolyl-tRNA synthetase (tgprs) in complex with tetrahydro… | x-ray diffraction | A, B, C, D | ANP, MG, 87C, CL | — |
| 5XIQ | Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Halofugi | x-ray diffraction | A, B, C, D | ANP, HFG, MG | 20 (best 0.82) |
| 5XIQ | Crystal structure of toxoplasma gondii prolyl-tRNA synthetase (tgprs) in complex with halofuginone | x-ray diffraction | A, B, C, D | ANP, HFG, MG | — |
| 6A88 | Crystal Structure of T. gondii prolyl tRNA synthetase with Febrifugine and ATP Analog | x-ray diffraction | A, B, C, D | ANP, MG, 9SF | 20 (best 0.83) |
| 6A88 | Crystal structure of T. gondii prolyl tRNA synthetase with febrifugine and ATP analog | x-ray diffraction | A, B, C, D | ANP, MG, 9SF | — |
| 6AA0 | Crystal structure of toxoplasma gondii prolyl tRNA synthetase (tgprs) in apo form | x-ray diffraction | A, B, C, D | — | — |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 12 records
- MG · Magnesium ion · in 12 records
- CL · Chloride ion · in 6 records
- 86X · 6-chloranyl-7-fluoranyl-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one · in 2 records
- 873 · 3-[(2R)-2-oxidanyl-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]quinazolin-4-one · in 2 records
- 87F · 3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one · in 2 records
- 9SF · 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one · in 2 records
- HFG · 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one · in 2 records
- 86U · 6,7-bis(fluoranyl)-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one · in 1 record
- 87C · 3-[2-oxidanylidene-3-[(2R,3R)-3-oxidanylpiperidin-2-yl]propyl]-5,6,7,8-tetrahydroquinazolin-4-one · in 1 record
Elsewhere
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