UniProt Q9ZHQ1

20-oxo-5-O-mycaminosyltylactone 23-monooxygenase (Q9ZHQ1)

20-oxo-5-O-mycaminosyltylactone 23-monooxygenase (UniProt Q9ZHQ1), EC 1.14.13.186: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 8 pockets. Binding sites, druggability and experiment against…

UniProt: Q9ZHQ1
Protein: 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
EC: 1.14.13.186
Experimental structures: 2
Predicted models: 1
Ligands: 2
Pockets: 8 · 2 records with a druggable one

Structures

3 records of Q9ZHQ1 in the MolNFT archive: 2 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6B11	TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)	x-ray diffraction	A, B	HEM, CGM	6 (best 0.88)
6B11	Tylhi in complex with native substrate 23-deoxy-5-O-mycaminosyl- tylonolide (23-dmtl)	x-ray diffraction	A, B	HEM, CGM	—
Q9ZHQ1	AlphaFold monomer V2.0 prediction for 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase (Q9ZHQ1)	predicted	A	—	2 (best 0.85)

Ligands

CGM · (4R,5S,6S,7R,9R,11E,13E,15S,16R)-16-ethyl-4-hydroxy-5, 9,13,15-tetramethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl 3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranoside · in 2 records
HEM · Protoporphyrin IX containing Fe · in 2 records

Experiment against prediction

6B11 chain B against the predicted model Q9ZHQ1: TM-score 0.97, RMSD 1.36 Å
6B11 chain B against the predicted model Q9ZHQ1: TM-score 0.97, RMSD 1.36 Å
6B11 chain A against the predicted model Q9ZHQ1: TM-score 0.96, RMSD 1.46 Å
6B11 chain A against the predicted model Q9ZHQ1: TM-score 0.96, RMSD 1.46 Å

Elsewhere

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