UniProt Q9ZGI2
Narbonolide/10-deoxymethynolide synthase PikA4, module 6 (Q9ZGI2)
Narbonolide/10-deoxymethynolide synthase PikA4, module 6 (UniProt Q9ZGI2), EC 2.3.1.239, 2.3.1.240: 17 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 21 pockets. Binding sites, druggability and…
- UniProt
- Q9ZGI2
- Protein
- Narbonolide/10-deoxymethynolide synthase PikA4, module 6
- EC
- 2.3.1.239, 2.3.1.240
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 21 · 2 records with a druggable one
Structures
18 records of Q9ZGI2 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MN6 | Thioesterase Domain from Picromycin Polyketide Synthase, pH 7.6 | x-ray diffraction | A, B | — | — |
| 1MN6 | Thioesterase domain from picromycin polyketide synthase, pH 7.6 | x-ray diffraction | A, B | — | — |
| 1MNA | Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0 | x-ray diffraction | A, B | — | — |
| 1MNA | Thioesterase domain of picromycin polyketide synthase (pics te), pH 8.0 | x-ray diffraction | A, B | — | — |
| 1MNQ | Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4 | x-ray diffraction | A, B | — | — |
| 1MNQ | Thioesterase domain of picromycin polyketide synthase (pics te), pH 8.4 | x-ray diffraction | A, B | — | — |
| 2H7X | Pikromycin Thioesterase adduct with reduced triketide affinity label | x-ray diffraction | A, B | — | — |
| 2H7X | Pikromycin thioesterase adduct with reduced triketide affinity label | x-ray diffraction | A, B | — | — |
| 2H7Y | Pikromycin Thioesterase with covalent affinity label | x-ray diffraction | A, B | — | — |
| 2H7Y | Pikromycin thioesterase with covalent affinity label | x-ray diffraction | A, B | — | — |
| 2HFJ | Pikromycin thioesterase with covalent pentaketide affinity label | x-ray diffraction | A, B | — | — |
| 2HFJ | Pikromycin thioesterase with covalent pentaketide affinity label | x-ray diffraction | A, B | — | — |
| 2HFK | Pikromycin thioesterase in complex with product 10-deoxymethynolide | x-ray diffraction | A, B | — | — |
| 2HFK | Pikromycin thioesterase in complex with product 10-deoxymethynolide | x-ray diffraction | A, B | — | — |
| 3F5H | Crystal structure of fused docking domains from PikAIII and PikAIV of the pikromycin polyketide… | x-ray diffraction | A, B | — | — |
| 3F5H | Crystal structure of fused docking domains from pikaiii and pikaiv of the pikromycin polyketide… | x-ray diffraction | A, B | — | — |
| 9CGN | Pikromycin Thioesterase with heptaketide adduct | x-ray diffraction | A, B | A1AWF | 4 (best 0.78) |
| Q9ZGI2 | AlphaFold monomer V2.0 prediction for NARBONOLIDE/10-deoxymethynolide synthase PIKA4, module 6… | predicted | A | — | 17 (best 0.78) |
Ligands
- A1AWF · (2S,4R,5S,6S,8R,12R,13R)-5,13-dihydroxy-2,4,6,8,12-pentamethyl-3,9-dioxopentadecanal · in 1 record
Experiment against prediction
- 2H7Y chain B against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.22 Å
- 2H7Y chain B against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.22 Å
- 2HFJ chain B against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.22 Å
- 2HFJ chain B against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.22 Å
- 2H7X chain A against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.21 Å
- 2H7X chain A against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.21 Å
- 2HFJ chain A against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.22 Å
- 2HFJ chain A against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.22 Å
- 9CGN chain B against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.23 Å
- 2H7Y chain A against the predicted model Q9ZGI2: TM-score 0.97, RMSD 1.22 Å
Elsewhere
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