UniProt Q9Y6W6
Dual specificity protein phosphatase 10 (Q9Y6W6)
Dual specificity protein phosphatase 10 (UniProt Q9Y6W6), EC 3.1.3.16, 3.1.3.48: 20 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 90 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9Y6W6
- Protein
- Dual specificity protein phosphatase 10
- EC
- 3.1.3.16, 3.1.3.48
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 90 · 12 records with a druggable one
Structures
21 records of Q9Y6W6 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZZW | Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5 | x-ray diffraction | A, B | SO4 | 3 (best 0.52) |
| 1ZZW | Crystal structure of catalytic domain of human MAP kinase phosphatase 5 | x-ray diffraction | A, B | SO4 | 3 (best 0.52) |
| 2OUC | Crystal structure of the MAP kinase binding domain of MKP5 | x-ray diffraction | A, B | — | — |
| 2OUC | Crystal structure of the MAP kinase binding domain of MKP5 | x-ray diffraction | A, B | — | — |
| 2OUD | Crystal structure of the catalytic domain of human MKP5 | x-ray diffraction | A | CL | — |
| 2OUD | Crystal structure of the catalytic domain of human MKP5 | x-ray diffraction | A | CL | — |
| 3TG1 | Crystal structure of p38alpha in complex with a MAPK docking partner | x-ray diffraction | B | — | 4 (best 0.50) |
| 3TG1 | Crystal structure of P38ALPHA in complex with a MAPK docking partner | x-ray diffraction | B | — | 4 (best 0.50) |
| 6MC1 | Structure of MAP kinase phosphatase 5 in complex with… | x-ray diffraction | A, B, C, D, E, F | CJA | 7 (best 0.81) |
| 6MC1 | Structure of MAP kinase phosphatase 5 in complex with 3,3-dimethyl-1… | x-ray diffraction | A, B, C, D, E, F | CJA | 7 (best 0.81) |
| 7U4O | Structure of MAP kinase phosphatase 5 in complex with… | x-ray diffraction | A, B, C, D, E, F | L8K | 10 (best 0.81) |
| 7U4R | Structure of MAP kinase phosphatase 5 in complex with… | x-ray diffraction | A, B, C, D, E, F | L8R | 10 (best 0.81) |
| 7UMU | Structure of MAP kinase phosphatase 5 in complex with… | x-ray diffraction | A, B, C, D, E, F | NUN | 12 (best 0.81) |
| 7UMV | Structure of MAP kinase phosphatase 5 in complex with… | x-ray diffraction | A | NUU | 1 (best 0.49) |
| 7UN0 | Structure of MAP kinase phosphatase 5 in complex with… | x-ray diffraction | A, B, C, D, E, F | NV3 | 8 (best 0.80) |
| 7UN4 | Structure of MAP kinase phosphatase 5 in complex with… | x-ray diffraction | A, B, C, D, E, F | NVF | 10 (best 0.82) |
| 7Y4B | Crystal structure of DUSP10 mutant_D59A | x-ray diffraction | A, B | — | 2 (best 0.47) |
| 7Y4C | Crystal structure of DUSP10 | x-ray diffraction | A, B, C, D | — | 5 (best 0.78) |
| 7Y4D | Crystal structure of DUSP10 mutant_S95A | x-ray diffraction | A, B | — | 3 (best 0.47) |
| 7Y4E | Crystal structure of DUSP10 mutant_N130A | x-ray diffraction | A, B | — | 1 (best 0.43) |
| Q9Y6W6 | AlphaFold monomer V2.0 prediction for dual specificity protein phosphatase 10 (Q9Y6W6) | predicted | A | — | — |
Ligands
- CJA · 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one · in 2 records
- CL · Chloride ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- L8K · 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one · in 1 record
- L8R · 3,3-dimethyl-1-{[(9aM)-9-propyl-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}butan-2-one · in 1 record
- NUN · 1-[(benzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one · in 1 record
- NUU · 1-{[(10aP)-5,6-dihydropyrido[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one · in 1 record
- NV3 · 1-[(9-chlorobenzo[h]quinazolin-2-yl)sulfanyl]-3,3-dimethylbutan-2-one · in 1 record
- NVF · 1-{[(9aM)-5,6-dihydrothieno[2,3-h]quinazolin-2-yl]sulfanyl}-3,3-dimethylbutan-2-one · in 1 record
Experiment against prediction
- 7Y4C chain B against the predicted model Q9Y6W6: TM-score 0.99, RMSD 0.41 Å
- 7Y4C chain A against the predicted model Q9Y6W6: TM-score 0.99, RMSD 0.42 Å
- 1ZZW chain A against the predicted model Q9Y6W6: TM-score 0.99, RMSD 0.43 Å
- 1ZZW chain A against the predicted model Q9Y6W6: TM-score 0.99, RMSD 0.43 Å
- 7Y4E chain A against the predicted model Q9Y6W6: TM-score 0.99, RMSD 0.47 Å
- 7Y4B chain A against the predicted model Q9Y6W6: TM-score 0.99, RMSD 0.60 Å
- 7UN0 chain B against the predicted model Q9Y6W6: TM-score 0.98, RMSD 0.72 Å
- 7Y4E chain B against the predicted model Q9Y6W6: TM-score 0.98, RMSD 0.70 Å
- 7UN0 chain C against the predicted model Q9Y6W6: TM-score 0.98, RMSD 0.78 Å
- 7U4R chain E against the predicted model Q9Y6W6: TM-score 0.98, RMSD 0.79 Å
Elsewhere
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