UniProt Q9Y6F1
Poly [ADP-ribose] polymerase 3 (Q9Y6F1)
Poly [ADP-ribose] polymerase 3 (UniProt Q9Y6F1), EC 2.4.2.30: 32 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9Y6F1
- Protein
- Poly [ADP-ribose] polymerase 3
- EC
- 2.4.2.30
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 12 · 5 records with a druggable one
Structures
33 records of Q9Y6F1 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2EOC | Solution structure of the WGR domain from human poly [ADP-ribose] polymerase-3 | solution nmr | A | — | 1 (best 0.37) |
| 2EOC | Solution structure of the wgr domain from human poly [ADP-ribose] polymerase-3 | solution nmr | A | — | — |
| 3C49 | Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor KU0058948 | x-ray diffraction | A | KU8 | 2 (best 0.75) |
| 3C49 | Human POLY(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor KU0058948 | x-ray diffraction | A | — | — |
| 3C4H | Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313 | x-ray diffraction | A | DRL | 2 (best 0.75) |
| 3C4H | Human POLY(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor DR2313 | x-ray diffraction | A | — | — |
| 3CE0 | Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor PJ34 | x-ray diffraction | A | P34 | 1 (best 0.75) |
| 3CE0 | Human POLY(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor PJ34 | x-ray diffraction | A | — | — |
| 3FHB | Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic… | x-ray diffraction | A | GAB | 1 (best 0.75) |
| 3FHB | Human POLY(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor 3-aminobenzoic… | x-ray diffraction | A | — | — |
| 4GV0 | Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0355 | x-ray diffraction | A | — | — |
| 4GV0 | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor ME0355 | x-ray diffraction | A | — | — |
| 4GV2 | Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0354 | x-ray diffraction | A | — | — |
| 4GV2 | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor ME0354 | x-ray diffraction | A | — | — |
| 4GV4 | Human ARTD3 (PARP3) - Catalytic domain in complex with inhibitor ME0328 | x-ray diffraction | A | — | — |
| 4GV4 | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor ME0328 | x-ray diffraction | A | — | — |
| 4L6Z | Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1168 | x-ray diffraction | A | — | — |
| 4L6Z | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor STO1168 | x-ray diffraction | A | — | — |
| 4L70 | Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0352 | x-ray diffraction | A | — | — |
| 4L70 | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor ME0352 | x-ray diffraction | A | — | — |
| 4L7L | Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0368 | x-ray diffraction | A | — | — |
| 4L7L | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor ME0368 | x-ray diffraction | A | — | — |
| 4L7N | Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1542 | x-ray diffraction | A | — | — |
| 4L7N | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor STO1542 | x-ray diffraction | A | — | — |
| 4L7O | Human artd3 (parp3) - catalytic domain in complex with inhibitor STO1542 | x-ray diffraction | A | — | — |
| 4L7O | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor STO1542 | x-ray diffraction | A | — | — |
| 4L7P | Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0395 | x-ray diffraction | A | — | — |
| 4L7P | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor ME0395 | x-ray diffraction | A | — | — |
| 4L7R | Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0400 | x-ray diffraction | A | — | — |
| 4L7R | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor ME0400 | x-ray diffraction | A | — | — |
| 4L7U | Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0398 | x-ray diffraction | A | — | — |
| 4L7U | Human ARTD3 (PARP3) - catalytic domain in complex with inhibitor ME0398 | x-ray diffraction | A | — | — |
| Q9Y6F1 | AlphaFold monomer V2.0 prediction for protein mono-ADP- ribosyltransferase PARP3 (Q9Y6F1) | predicted | A | — | 5 (best 0.75) |
Ligands
- DRL · 2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one · in 1 record
- GAB · 3-aminobenzoic acid · in 1 record
- KU8 · 4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one · in 1 record
- P34 · N~2~,N~2~-dimethyl-N~1~-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide · in 1 record
Experiment against prediction
- 4L7O chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.65 Å
- 4L7O chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.65 Å
- 4GV0 chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.65 Å
- 4GV0 chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.65 Å
- 4L70 chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.65 Å
- 4L70 chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.65 Å
- 3C4H chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.67 Å
- 3C4H chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.67 Å
- 3FHB chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.67 Å
- 3FHB chain A against the predicted model Q9Y6F1: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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