UniProt Q9Y5Y6
Suppressor of tumorigenicity 14 protein (Q9Y5Y6)
Suppressor of tumorigenicity 14 protein (UniProt Q9Y5Y6), EC 3.4.21.-, 3.4.21.109: 44 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 34 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9Y5Y6
- Protein
- Suppressor of tumorigenicity 14 protein
- EC
- 3.4.21.-, 3.4.21.109
- Experimental structures
- 44
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 34 · 2 records with a druggable one
Structures
45 records of Q9Y5Y6 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EAW | Crystal structure of the MTSP1 (matriptase)-BPTI (aprotinin) complex | x-ray diffraction | A, C | — | 4 (best 0.44) |
| 1EAW | Crystal structure of the MTSP1 (matriptase)-bpti (aprotinin) complex | x-ray diffraction | A, C | — | — |
| 1EAX | Crystal structure of MTSP1 (matriptase) | x-ray diffraction | A | SO4, BEN | 1 (best 0.39) |
| 1EAX | Crystal structure of MTSP1 (matriptase) | x-ray diffraction | A | — | — |
| 2GV6 | Crystal Structure of Matriptase with Inhibitor CJ-730 | x-ray diffraction | A | 730 | 1 (best 0.37) |
| 2GV6 | Crystal structure of matriptase with inhibitor cj-730 | x-ray diffraction | A | — | — |
| 2GV7 | Structure of Matriptase in Complex with Inhibitor CJ-672 | x-ray diffraction | A | 672 | 2 (best 0.36) |
| 2GV7 | Structure of matriptase in complex with inhibitor cj-672 | x-ray diffraction | A | — | — |
| 3BN9 | Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2 | x-ray diffraction | B, A | — | — |
| 3BN9 | Crystal structure of mt-SP1 in complex with Fab inhibitor E2 | x-ray diffraction | B, A | — | — |
| 3NCL | Crystal Structure of MT-SP1 bound to Benzamidine Phosphonate Inhibitor | x-ray diffraction | A | — | — |
| 3NCL | Crystal structure of mt-SP1 bound to benzamidine phosphonate inhibitor | x-ray diffraction | A | — | — |
| 3NPS | Crystal structure of membrane-type serine protease 1 (MT-SP1) in complex with the Fab Inhibitor S4 | x-ray diffraction | A | — | — |
| 3NPS | Crystal structure of membrane-type serine protease 1 (mt-SP1) in complex with the Fab inhibitor S4 | x-ray diffraction | A | — | — |
| 3SO3 | Structures of Fab-Protease Complexes Reveal a Highly Specific Non-Canonical Mechanism of Inhibition. | x-ray diffraction | A | — | — |
| 3SO3 | Structures of Fab-protease complexes reveal a highly specific non- canonical mechanism of… | x-ray diffraction | A | — | — |
| 4IS5 | Crystal Structure of the ligand-free inactive Matriptase | x-ray diffraction | A | — | — |
| 4IS5 | Crystal structure of the ligand-free inactive matriptase | x-ray diffraction | A | — | — |
| 4ISL | Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1 | x-ray diffraction | A | — | — |
| 4ISL | Crystal structure of the inactive matriptase in complex with its inhibitor hai-1 | x-ray diffraction | A | — | — |
| 4ISN | Crystal Structure of Matriptase in complex with its inhibitor HAI-1 | x-ray diffraction | A | — | — |
| 4ISN | Crystal structure of matriptase in complex with its inhibitor hai-1 | x-ray diffraction | A | — | — |
| 4ISO | Crystal Structure of Matriptase in complex with its inhibitor HAI-1 | x-ray diffraction | A | — | — |
| 4ISO | Crystal structure of matriptase in complex with its inhibitor hai-1 | x-ray diffraction | A | — | — |
| 4JYT | Crystal Structure of Matriptase in complex with Inhibitor | x-ray diffraction | A | — | — |
| 4JYT | Crystal structure of matriptase in complex with inhibitor | x-ray diffraction | A | — | — |
| 4JZ1 | Crystal Structure of Matriptase in complex with Inhibitor | x-ray diffraction | A | — | — |
| 4JZ1 | Crystal structure of matriptase in complex with inhibitor | x-ray diffraction | A | — | — |
| 4JZI | Crystal Structure of Matriptase in complex with Inhibitor". | x-ray diffraction | A | — | — |
| 4JZI | Crystal structure of matriptase in complex with inhibitor". | x-ray diffraction | A | — | — |
| 4O97 | Crystal structure of matriptase in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4O97 | Crystal structure of matriptase in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4O9V | Crystal structure of matriptase in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4O9V | Crystal structure of matriptase in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 4R0I | CRYSTAL STRUCTURE of MATRIPTASE in COMPLEX WITH INHIBITOR | x-ray diffraction | A, B | — | — |
| 4R0I | Crystal structure of matriptase in complex with inhibitor | x-ray diffraction | A, B | — | — |
| 5LYO | Crystal structure of the zymogen matriptase catalytic domain | x-ray diffraction | A, B, C | SO4 | 11 (best 0.70) |
| 5LYO | Crystal structure of the zymogen matriptase catalytic domain | x-ray diffraction | A, B, C | SO4 | — |
| 6N4T | Crystal structure of Matriptase1 in complex with a peptidomimetic benzothiazole | x-ray diffraction | A | MG, GSH, KD7 | — |
| 6N4T | Crystal structure of MATRIPTASE1 in complex with a peptidomimetic benzothiazole | x-ray diffraction | A | MG, GSH, KD7 | — |
| 6T9T | Matriptase in complex with the synthetic inhibitor (S)-3-(3-(4-(3-(tert-butyl)ureido)piperidin-1-yl)… | x-ray diffraction | A | CL, MXH | 1 (best 0.47) |
| 6T9T | Matriptase in complex with the synthetic inhibitor (S)-3-(3-(4-(3… | x-ray diffraction | A | CL, MXH | — |
| 8G1V | Crystal Structure Matriptase (C731S) in Complex with Inhibitor MM1132-2 | x-ray diffraction | A | SO4, CL, YIL | 1 (best 0.46) |
| 8G1W | Crystal Structure Matriptase (C731S) in Complex with Inhibitor VD4162B | x-ray diffraction | A | CL | 1 (best 0.41) |
| Q9Y5Y6 | AlphaFold monomer V2.0 prediction for suppressor of tumorigenicity 14 protein (Q9Y5Y6) | predicted | A | — | 12 (best 0.62) |
Ligands
- CL · Chloride ion · in 4 records
- SO4 · Sulfate ion · in 4 records
- GSH · Glutathione · in 2 records
- KD7 · N-(3-phenylpropanoyl)-3-(1,3-thiazol-4-yl)-L-alanyl-N-[(1S,2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-valinamide · in 2 records
- MG · Magnesium ion · in 2 records
- MXH · 1-~{tert}-butyl-3-[1-[(2~{S})-3-(3-carbamimidoylphenyl)-2-[[3-[3-fluoranyl-4-(hydroxymethyl)phenyl]phenyl]sulfonylamino ]propanoyl]piperidin-4-yl]urea · in 2 records
- 672 · (S)-4-(4-(3-(3-carbamimidoylphenyl)-2-(2,4,6-triisopropylphenylsulfonamido)propanoyl)piperazine-1-carbonyl)piperidine-1-carboximidamide · in 1 record
- 730 · (S)-3-(3-(4-(2-guanidinoethyl)piperidin-1-yl)-2-(naphthalene-2-sulfonamido)-3-oxopropyl)benzimidamide · in 1 record
- BEN · Benzamidine · in 1 record
- YIL · N~2~-{[3-(acetamidomethyl)phenyl]acetyl}-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1,1-dihydroxypentan-2-yl]-L-leucinamide · in 1 record
Experiment against prediction
- 4ISL chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.73 Å
- 4ISL chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.73 Å
- 4ISN chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.74 Å
- 4ISN chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.74 Å
- 4ISO chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.79 Å
- 4ISO chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.79 Å
- 6N4T chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.79 Å
- 6N4T chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.79 Å
- 3SO3 chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.81 Å
- 3SO3 chain A against the predicted model Q9Y5Y6: TM-score 0.99, RMSD 0.81 Å
Elsewhere
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