UniProt Q9Y572
Receptor-interacting serine/threonine-protein kinase 3 (Q9Y572)
Receptor-interacting serine/threonine-protein kinase 3 (UniProt Q9Y572), EC 2.7.11.1: 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 24 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9Y572
- Protein
- Receptor-interacting serine/threonine-protein kinase 3
- EC
- 2.7.11.1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 24 · 3 records with a druggable one
Structures
11 records of Q9Y572 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ZCK | Structure of the RIP3 core region | x-ray diffraction | A | NA | — |
| 5ZCK | Structure of the RIP3 core region | x-ray diffraction | A | NA | — |
| 7DA4 | Cryo-EM structure of amyloid fibril formed by human RIPK3 | electron microscopy | B, A, C | — | — |
| 7DA4 | Cryo-EM structure of amyloid fibril formed by human RIPK3 | electron microscopy | B, A, C | — | — |
| 7DAC | Human RIPK3 amyloid fibril revealed by solid-state NMR | solid-state nmr | A, B, C, D, E | — | 2 (best 0.44) |
| 7DAC | Human RIPK3 amyloid fibril revealed by solid-state NMR | solid-state nmr | A, B, C, D, E | — | — |
| 7MON | Structure of human RIPK3-MLKL complex | x-ray diffraction | B | ZL1 | 4 (best 0.70) |
| 7MON | Structure of human RIPK3-mlkl complex | x-ray diffraction | B | ZL1 | — |
| 7MX3 | Crystal structure of human RIPK3 complexed with GSK'843 | x-ray diffraction | A, B, C, D | ZOV | 14 (best 0.70) |
| 7MX3 | Crystal structure of human RIPK3 complexed with GSK'843 | x-ray diffraction | A, B, C, D | ZOV | — |
| Q9Y572 | AlphaFold monomer V2.0 prediction for receptor-interacting SERINE/THREONINE-protein kinase 3… | predicted | A | — | 4 (best 0.70) |
Ligands
Experiment against prediction
- 7MX3 chain C against the predicted model Q9Y572: TM-score 0.95, RMSD 1.79 Å
- 7MX3 chain C against the predicted model Q9Y572: TM-score 0.95, RMSD 1.79 Å
- 7MX3 chain B against the predicted model Q9Y572: TM-score 0.95, RMSD 1.47 Å
- 7MX3 chain B against the predicted model Q9Y572: TM-score 0.95, RMSD 1.47 Å
- 7MX3 chain D against the predicted model Q9Y572: TM-score 0.95, RMSD 1.70 Å
- 7MX3 chain D against the predicted model Q9Y572: TM-score 0.95, RMSD 1.70 Å
- 7MX3 chain A against the predicted model Q9Y572: TM-score 0.95, RMSD 1.91 Å
- 7MX3 chain A against the predicted model Q9Y572: TM-score 0.95, RMSD 1.91 Å
- 7MON chain B against the predicted model Q9Y572: TM-score 0.94, RMSD 1.96 Å
- 7MON chain B against the predicted model Q9Y572: TM-score 0.94, RMSD 1.96 Å
Elsewhere
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