UniProt Q9Y2X0
Mediator of RNA polymerase II transcription subunit 16 (Q9Y2X0)
Mediator of RNA polymerase II transcription subunit 16 (UniProt Q9Y2X0): 12 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 40 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9Y2X0
- Protein
- Mediator of RNA polymerase II transcription subunit 16
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 40 · 9 records with a druggable one
Structures
13 records of Q9Y2X0 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | P | ZN | 5 (best 0.86) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | P | ZN | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | p | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | p | — | — |
| 7ENJ | Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) | electron microscopy | P | — | 3 (best 0.86) |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | P | — | — |
| 7LBM | Structure of the human Mediator-bound transcription pre-initiation complex | electron microscopy | 0 | — | 4 (best 0.84) |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | p | ZN | 2 (best 0.87) |
| 8GXS | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | electron microscopy | p | ZN | 4 (best 0.86) |
| 8T9D | CryoEM structure of TR-TRAP | electron microscopy | K | — | 5 (best 0.87) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | P | ZN | 5 (best 0.86) |
| 8TRH | The IDRc bound human core Mediator complex | electron microscopy | P | ZN | 4 (best 0.85) |
| Q9Y2X0 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 16… | predicted | A | — | 8 (best 0.84) |
Ligands
- ZN · Zinc ion · in 6 records
Experiment against prediction
- 7ENJ chain P against the predicted model Q9Y2X0: TM-score 0.96, RMSD 1.77 Å
- 7ENJ chain P against the predicted model Q9Y2X0: TM-score 0.96, RMSD 1.77 Å
- 7ENC chain p against the predicted model Q9Y2X0: TM-score 0.96, RMSD 1.78 Å
- 7ENA chain p against the predicted model Q9Y2X0: TM-score 0.96, RMSD 1.79 Å
- 7EMF chain P against the predicted model Q9Y2X0: TM-score 0.95, RMSD 2.30 Å
- 7EMF chain P against the predicted model Q9Y2X0: TM-score 0.95, RMSD 2.30 Å
- 8GXQ chain p against the predicted model Q9Y2X0: TM-score 0.95, RMSD 2.30 Å
- 8GXS chain p against the predicted model Q9Y2X0: TM-score 0.95, RMSD 2.30 Å
- 7LBM chain 0 against the predicted model Q9Y2X0: TM-score 0.95, RMSD 2.21 Å
- 8TRH chain P against the predicted model Q9Y2X0: TM-score 0.94, RMSD 2.70 Å
Elsewhere
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