UniProt Q9Y2U9
Kelch domain-containing protein 2 (Q9Y2U9)
Kelch domain-containing protein 2 (UniProt Q9Y2U9): 17 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 81 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y2U9
- Protein
- Kelch domain-containing protein 2
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 81 · 14 records with a druggable one
Structures
18 records of Q9Y2U9 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6DO3 | KLHDC2 ubiquitin ligase in complex with SelK C-end degron | x-ray diffraction | A, B | — | 6 (best 0.79) |
| 6DO3 | KLHDC2 ubiquitin ligase in complex with selk C-end degron | x-ray diffraction | A, B | — | — |
| 6DO4 | KLHDC2 ubiquitin ligase in complex with SelS C-end degron | x-ray diffraction | A, B | — | 3 (best 0.79) |
| 6DO4 | KLHDC2 ubiquitin ligase in complex with sels C-end degron | x-ray diffraction | A, B | — | — |
| 6DO5 | KLHDC2 ubiquitin ligase in complex with USP1 C-end degron | x-ray diffraction | A, B | — | 3 (best 0.79) |
| 6DO5 | KLHDC2 ubiquitin ligase in complex with USP1 C-end degron | x-ray diffraction | A, B | — | — |
| 8EBL | Structure of KLHDC2 substrate binding domain bound to C-degron from EPHB2 | x-ray diffraction | A, B | — | 5 (best 0.80) |
| 8EBM | Structure of KLHDC2 substrate binding domain bound to KLHDC2's C-degron mimic | x-ray diffraction | A, B | — | 3 (best 0.79) |
| 8EBN | Structure of KLHDC2-EloB/C tetrameric assembly | x-ray diffraction | A, B | — | 10 (best 0.79) |
| 8PIF | Fragment 12 in complex with KLHDC2 | x-ray diffraction | A, B | YW6 | 5 (best 0.79) |
| 8SGE | KLHDC2 Kelch Domain with ligand KDRLKZ-1 | x-ray diffraction | A, B | ZWS | 5 (best 0.79) |
| 8SGF | KLHDC2 Kelch Domain with KLHDC2 c-terminal peptide bound | x-ray diffraction | A, B | — | 5 (best 0.79) |
| 8SH2 | KLHDC2 in complex with EloB and EloC | electron microscopy | B, C, A, D | — | 16 (best 0.87) |
| 8UXS | KLHDC2 ubiquitin ligase in complex with a novel small-molecule | x-ray diffraction | A, B | XU8 | 5 (best 0.79) |
| 9BC9 | Structure of KLHDC2 bound to SJ10278 | x-ray diffraction | A, B | A1APK, NCO | 5 (best 0.79) |
| 9BCA | Structure of KLHDC2 bound to SJ46411 | x-ray diffraction | A, B | A1APS, NCO | 5 (best 0.78) |
| 9BCC | Structure of KLHDC2 bound to SJ46418 | x-ray diffraction | A, B | A1APT, NCO | 5 (best 0.79) |
| Q9Y2U9 | AlphaFold monomer V2.0 prediction for kelch domain-containing protein 2 (Q9Y2U9) | predicted | A | — | — |
Ligands
- NCO · Cobalt hexammine(iii) · in 3 records
- A1APK · N-({2-[2-chloro-4-(methoxymethoxy)phenyl]-1,3-thiazol-4-yl}acetyl)glycine · in 1 record
- A1APS · N-{[2-(naphthalen-2-yl)-1,3-thiazol-4-yl]acetyl}glycine · in 1 record
- A1APT · N-({2-[8-(2-methoxyethoxy)naphthalen-2-yl]-1,3-thiazol-4-yl}acetyl)glycine · in 1 record
- XU8 · {4-[(2-{[(4-tert-butylphenyl)methyl]sulfanyl}acetamido)methyl]-1H-1,2,3-triazol-1-yl}acetic acid · in 1 record
- YW6 · 2-(furan-3-yl)ethanoic acid · in 1 record
- ZWS · [(5P)-5-{3-[(2R)-butan-2-yl]-7-[(2-methoxyethoxy)carbonyl]-2-oxo-5,6,7,8-tetrahydro-1,7-naphthyridin-1(2H)-yl}-2-oxopyridin-1(2H)-yl]acetic acid · in 1 record
Experiment against prediction
- 8PIF chain B against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.21 Å
- 8PIF chain A against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.22 Å
- 6DO5 chain A against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.24 Å
- 6DO5 chain A against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.24 Å
- 6DO4 chain A against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.25 Å
- 6DO4 chain A against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.25 Å
- 8UXS chain A against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.25 Å
- 6DO3 chain B against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.27 Å
- 6DO3 chain B against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.27 Å
- 8UXS chain B against the predicted model Q9Y2U9: TM-score 1.00, RMSD 0.28 Å
Elsewhere
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