UniProt Q9Y2T6
G-protein coupled receptor 55 (Q9Y2T6)
G-protein coupled receptor 55 (UniProt Q9Y2T6): 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y2T6
- Protein
- G-protein coupled receptor 55
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 21 · 4 records with a druggable one
Structures
5 records of Q9Y2T6 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8ZX4 | LPI-bound GPR55 in complex with G13 | electron microscopy | R | A1D9E | 4 (best 0.76) |
| 8ZX5 | AM251-bound GPR55 in complex with G13 | electron microscopy | R | A1D9D | 6 (best 0.79) |
| 9IY8 | Cryo-EM structure of apo-GPR55-G13 complex | electron microscopy | R | — | 5 (best 0.72) |
| 9IYA | Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex | electron microscopy | A | A1L3E | 6 (best 0.76) |
| Q9Y2T6 | AlphaFold monomer V2.0 prediction for G-protein coupled receptor 55 (Q9Y2T6) | predicted | A | — | — |
Ligands
- A1D9D · 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-~{N}-piperidin-1-yl-pyrazole-3-carboxamide · in 1 record
- A1D9E · [(2~{R})-2-oxidanyl-3-[oxidanyl-[(2~{S},3~{R},5~{R},6~{R})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl] hexadecanoate · in 1 record
- A1L3E · 4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{N}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{H}-quinoline-3-carboxamide · in 1 record
Experiment against prediction
- 8ZX4 chain R against the predicted model Q9Y2T6: TM-score 0.96, RMSD 1.48 Å
- 8ZX5 chain R against the predicted model Q9Y2T6: TM-score 0.96, RMSD 1.39 Å
- 9IY8 chain R against the predicted model Q9Y2T6: TM-score 0.91, RMSD 2.12 Å
- 9IYA chain A against the predicted model Q9Y2T6: TM-score 0.71, RMSD 1.82 Å
- 9IYA chain A against the predicted model P0ABE7: TM-score 0.25, RMSD 2.86 Å
Elsewhere
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