UniProt Q9Y2L1

Exosome complex exonuclease RRP44 (Q9Y2L1)

Exosome complex exonuclease RRP44 (UniProt Q9Y2L1), EC 3.1.13.-, 3.1.26.-: 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q9Y2L1
Protein: Exosome complex exonuclease RRP44
EC: 3.1.13.-, 3.1.26.-
Experimental structures: 6
Predicted models: 1
Ligands: 2
Pockets: 28 · 3 records with a druggable one

Structures

7 records of Q9Y2L1 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6D6Q	Human nuclear exosome-MTR4 RNA complex - overall reconstruction	electron microscopy	K	MG, ZN	7 (best 0.86)
6D6Q	Human nuclear exosome-MTR4 RNA complex - overall reconstruction	electron microscopy	K	MG, ZN	—
6D6R	Human nuclear exosome-MTR4 RNA complex - composite map after focused reconstruction	electron microscopy	K	ZN, MG	8 (best 0.85)
6D6R	Human nuclear exosome-MTR4 RNA complex - composite MAP after focused reconstruction	electron microscopy	K	ZN, MG	—
6H25	Human nuclear RNA exosome EXO-10-MPP6 complex	electron microscopy	J	—	—
6H25	Human nuclear RNA exosome exo-10-MPP6 complex	electron microscopy	J	—	—
Q9Y2L1	AlphaFold monomer V2.0 prediction for exosome complex exonuclease RRP44 (Q9Y2L1)	predicted	A	—	13 (best 0.72)

Ligands

MG · Magnesium ion · in 4 records
ZN · Zinc ion · in 4 records

Experiment against prediction

6D6Q chain K against the predicted model Q9Y2L1: TM-score 0.72, RMSD 2.36 Å
6D6Q chain K against the predicted model Q9Y2L1: TM-score 0.72, RMSD 2.36 Å
6D6R chain K against the predicted model Q9Y2L1: TM-score 0.72, RMSD 2.38 Å
6D6R chain K against the predicted model Q9Y2L1: TM-score 0.72, RMSD 2.38 Å
6H25 chain J against the predicted model Q9Y2L1: TM-score 0.71, RMSD 2.73 Å
6H25 chain J against the predicted model Q9Y2L1: TM-score 0.71, RMSD 2.73 Å

Elsewhere

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