UniProt Q9XFH4
ATP-dependent DNA helicase DDM1 (Q9XFH4)
ATP-dependent DNA helicase DDM1 (UniProt Q9XFH4), EC 3.6.4.12: 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 62 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9XFH4
- Protein
- ATP-dependent DNA helicase DDM1
- EC
- 3.6.4.12
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 62 · 9 records with a druggable one
Structures
10 records of Q9XFH4 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7UX9 | Arabidopsis DDM1 bound to nucleosome (H2A.W, H2B, H3.3, H4, with 147 bp DNA) | electron microscopy | P | — | 9 (best 0.79) |
| 8J90 | Cryo-EM structure of DDM1-nucleosome complex | electron microscopy | K | — | 7 (best 0.84) |
| 8KCB | Complex of DDM1-nucleosome(H2A) complex with DDM1 bound to SHL2 | electron microscopy | K | BEF, ADP | 5 (best 0.86) |
| 8KCC | Complex of DDM1-nucleosome(H2A.W) complex with DDM1 bound to SHL2 | electron microscopy | K | ADP, BEF | 7 (best 0.80) |
| 8SKZ | Cryo-EM structure of DDM1-HELLS chimera bound to the nucleosome | electron microscopy | A | ADP, BEF | 6 (best 0.84) |
| 8WH5 | Structure of DDM1-nucleosome complex in the apo state | electron microscopy | K | — | 5 (best 0.80) |
| 8WH8 | Structure of DDM1-nucleosome complex in ADP state | electron microscopy | K | ADP | 6 (best 0.83) |
| 8WH9 | Structure of DDM1-nucleosome complex in ADP-BeFx state | electron microscopy | K | BEF, ADP | 6 (best 0.86) |
| 8WHA | Structure of DDM1-nucleosome complex in the ADP-BeFx state with DDM1 bound to SHL2 and SHL-2 | electron microscopy | K, L | BEF, ADP | 11 (best 0.86) |
| Q9XFH4 | AlphaFold monomer V2.0 prediction for ATP-dependent DNA helicase DDM1 (Q9XFH4) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8KCB chain K against the predicted model Q9XFH4: TM-score 0.93, RMSD 2.43 Å
- 8WHA chain L against the predicted model Q9XFH4: TM-score 0.92, RMSD 2.25 Å
- 8WH9 chain K against the predicted model Q9XFH4: TM-score 0.92, RMSD 2.25 Å
- 8WHA chain K against the predicted model Q9XFH4: TM-score 0.92, RMSD 2.26 Å
- 8KCC chain K against the predicted model Q9XFH4: TM-score 0.92, RMSD 2.63 Å
- 8SKZ chain A against the predicted model Q9XFH4: TM-score 0.88, RMSD 2.78 Å
- 8WH8 chain K against the predicted model Q9XFH4: TM-score 0.87, RMSD 3.01 Å
- 8WH5 chain K against the predicted model Q9XFH4: TM-score 0.86, RMSD 3.12 Å
- 8J90 chain K against the predicted model Q9XFH4: TM-score 0.86, RMSD 3.46 Å
- 8SKZ chain A against the predicted model Q9NRZ9: TM-score 0.83, RMSD 3.08 Å
Elsewhere
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