UniProt Q9WYW0
NAD-dependent protein deacetylase (Q9WYW0)
NAD-dependent protein deacetylase (UniProt Q9WYW0): 32 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9WYW0
- Protein
- NAD-dependent protein deacetylase
- Experimental structures
- 32
- Predicted models
- 1
- Pockets
- 1 · 1 record with a druggable one
Structures
33 records of Q9WYW0 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YC5 | Sir2-p53 peptide-nicotinamide | x-ray diffraction | A | — | — |
| 1YC5 | SIR2-P53 peptide-nicotinamide | x-ray diffraction | A | — | — |
| 2H2D | The Structural Basis for Sirtuin Substrate Affinity | x-ray diffraction | A | — | — |
| 2H2D | The structural basis for sirtuin substrate affinity | x-ray diffraction | A | — | — |
| 2H2F | The Structural basis for Sirtuin Substrate affinity | x-ray diffraction | A | — | — |
| 2H2F | The structural basis for sirtuin substrate affinity | x-ray diffraction | A | — | — |
| 2H2G | The Structural Basis of Sirtuin substrate affinity | x-ray diffraction | A | — | — |
| 2H2G | The structural basis of sirtuin substrate affinity | x-ray diffraction | A | — | — |
| 2H2H | The Structural basis of sirtuin substrate specificity | x-ray diffraction | A | — | — |
| 2H2H | The structural basis of sirtuin substrate specificity | x-ray diffraction | A | — | — |
| 2H2I | The Structural basis of Sirtuin Substrate Affinity | x-ray diffraction | A | — | — |
| 2H2I | The structural basis of sirtuin substrate affinity | x-ray diffraction | A | — | — |
| 2H4F | Sir2-p53 peptide-NAD+ | x-ray diffraction | A | — | — |
| 2H4F | SIR2-P53 peptide-NAD+ | x-ray diffraction | A | — | — |
| 2H4H | Sir2 H116Y mutant-p53 peptide-NAD | x-ray diffraction | A | — | — |
| 2H4H | SIR2 H116Y mutant-P53 peptide-NAD | x-ray diffraction | A | — | — |
| 2H4J | Sir2-deacetylated peptide (from enzymatic turnover in crystal) | x-ray diffraction | A | — | — |
| 2H4J | SIR2-deacetylated peptide (from enzymatic turnover in crystal) | x-ray diffraction | A | — | — |
| 2H59 | Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose | x-ray diffraction | A, B | — | — |
| 2H59 | SIR2 H116A-deacetylated P53 peptide-3'-O-acetyl ADP ribose | x-ray diffraction | A, B | — | — |
| 3D4B | Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+ | x-ray diffraction | A | — | — |
| 3D4B | Crystal structure of SIR2TM in complex with acetyl P53 peptide and dadme-NAD+ | x-ray diffraction | A | — | — |
| 3D81 | Sir2-S-alkylamidate complex crystal structure | x-ray diffraction | A | — | — |
| 3D81 | SIR2-S-alkylamidate complex crystal structure | x-ray diffraction | A | — | — |
| 3JR3 | Sir2 bound to acetylated peptide | x-ray diffraction | A | — | — |
| 3JR3 | SIR2 bound to acetylated peptide | x-ray diffraction | A | — | — |
| 3PDH | Structure of Sir2Tm bound to a propionylated peptide | x-ray diffraction | A | — | — |
| 3PDH | Structure of SIR2TM bound to a propionylated peptide | x-ray diffraction | A | — | — |
| 4BUZ | SIR2 complex structure mixture of ex-527 inhibitor and reaction products or of reaction substrates… | x-ray diffraction | A | — | — |
| 4BUZ | SIR2 complex structure mixture of ex-527 inhibitor and reaction products or of reaction substrates… | x-ray diffraction | A | — | — |
| 4BV2 | Crystal structure of SIR2 in complex with the inhibitor ex-527, 2'-O-acetyl-ADP-ribose and… | x-ray diffraction | A, B | — | — |
| 4BV2 | Crystal structure of SIR2 in complex with the inhibitor ex-527, 2'-O-acetyl-ADP-ribose and… | x-ray diffraction | A, B | — | — |
| Q9WYW0 | AlphaFold monomer V2.0 prediction for NAD-dependent protein deacetylase (Q9WYW0) | predicted | A | — | 1 (best 0.75) |
Experiment against prediction
- 2H59 chain A against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.45 Å
- 2H59 chain A against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.45 Å
- 4BV2 chain A against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.65 Å
- 4BV2 chain A against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.65 Å
- 4BV2 chain B against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.73 Å
- 4BV2 chain B against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.73 Å
- 3D4B chain A against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.72 Å
- 3D4B chain A against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.72 Å
- 4BUZ chain A against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.80 Å
- 4BUZ chain A against the predicted model Q9WYW0: TM-score 0.99, RMSD 0.80 Å
Elsewhere
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