UniProt Q9W138
S-adenosylmethionine sensor upstream of mTORC1 (Q9W138)
S-adenosylmethionine sensor upstream of mTORC1 (UniProt Q9W138), EC 2.1.1.-: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 41 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9W138
- Protein
- S-adenosylmethionine sensor upstream of mTORC1
- EC
- 2.1.1.-
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 41 · 4 records with a druggable one
Structures
7 records of Q9W138 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7VKK | Crystal structure of D. melanogaster SAMTOR V66W/E67P mutant | x-ray diffraction | A, B | SO4 | 9 (best 0.76) |
| 7VKK | Crystal structure of D. melanogaster samtor V66W/E67P mutant | x-ray diffraction | A, B | SO4 | — |
| 7VKQ | Crystal structure of D. melanogaster SAMTOR in the SAH bound form | x-ray diffraction | A, B, C, D | SAH | 15 (best 0.78) |
| 7VKQ | Crystal structure of D. melanogaster samtor in the sah bound form | x-ray diffraction | A, B, C, D | — | — |
| 7VKR | Crystal structure of D. melanogaster SAMTOR in complex with SAM | x-ray diffraction | A, B, C, D | SAM | 14 (best 0.78) |
| 7VKR | Crystal structure of D. melanogaster samtor in complex with SAM | x-ray diffraction | A, B, C, D | — | — |
| Q9W138 | AlphaFold monomer V2.0 prediction for S-adenosylmethionine sensor upstream of MTORC1 (Q9W138) | predicted | A | — | 3 (best 0.75) |
Ligands
Experiment against prediction
- 7VKR chain B against the predicted model Q9W138: TM-score 0.99, RMSD 0.61 Å
- 7VKR chain A against the predicted model Q9W138: TM-score 0.99, RMSD 0.63 Å
- 7VKR chain C against the predicted model Q9W138: TM-score 0.99, RMSD 0.61 Å
- 7VKR chain B against the predicted model Q9W138: TM-score 0.98, RMSD 0.61 Å
- 7VKR chain A against the predicted model Q9W138: TM-score 0.98, RMSD 0.63 Å
- 7VKR chain C against the predicted model Q9W138: TM-score 0.98, RMSD 0.61 Å
- 7VKR chain D against the predicted model Q9W138: TM-score 0.98, RMSD 0.83 Å
- 7VKQ chain B against the predicted model Q9W138: TM-score 0.98, RMSD 1.04 Å
- 7VKR chain D against the predicted model Q9W138: TM-score 0.98, RMSD 0.83 Å
- 7VKQ chain A against the predicted model Q9W138: TM-score 0.98, RMSD 1.07 Å
Elsewhere
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