UniProt Q9V461

DNA replication licensing factor Mcm6 (Q9V461)

DNA replication licensing factor Mcm6 (UniProt Q9V461), EC 3.6.4.12: 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q9V461
Protein: DNA replication licensing factor Mcm6
EC: 3.6.4.12
Experimental structures: 7
Predicted models: 1
Ligands: 2
Pockets: 8 · 2 records with a druggable one

Structures

8 records of Q9V461 in the MolNFT archive: 7 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6RAW	D. melanogaster cmg-DNA, state 1A	electron microscopy	6	ATP, ADP	—
6RAX	D. melanogaster CMG-DNA, State 1B	electron microscopy	6	ATP, ADP	—
6RAX	D. melanogaster cmg-DNA, state 1B	electron microscopy	6	ATP, ADP	—
6RAY	D. melanogaster CMG-DNA, State 2A	electron microscopy	6	ATP	3 (best 0.89)
6RAY	D. melanogaster cmg-DNA, state 2A	electron microscopy	6	ATP	—
6RAZ	D. melanogaster CMG-DNA, State 2B	electron microscopy	6	ADP, ATP	5 (best 0.89)
6RAZ	D. melanogaster cmg-DNA, state 2B	electron microscopy	6	ADP, ATP	—
Q9V461	AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM6 (Q9V461)	predicted	A	—	—

Ligands

ATP · Adenosine-5'-triphosphate · in 7 records
ADP · Adenosine-5'-diphosphate · in 5 records

Experiment against prediction

6RAY chain 6 against the predicted model Q9V461: TM-score 0.85, RMSD 3.84 Å
6RAY chain 6 against the predicted model Q9V461: TM-score 0.85, RMSD 3.84 Å
6RAZ chain 6 against the predicted model Q9V461: TM-score 0.84, RMSD 3.86 Å
6RAZ chain 6 against the predicted model Q9V461: TM-score 0.84, RMSD 3.86 Å
6RAW chain 6 against the predicted model Q9V461: TM-score 0.72, RMSD 5.74 Å
6RAX chain 6 against the predicted model Q9V461: TM-score 0.72, RMSD 5.73 Å
6RAX chain 6 against the predicted model Q9V461: TM-score 0.72, RMSD 5.73 Å

Elsewhere

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