UniProt Q9UQF2
SH3 domain of JNK-interacting Protein 1 (JIP1) (Q9UQF2)
SH3 domain of JNK-interacting Protein 1 (JIP1) (UniProt Q9UQF2), EC 3.1.3.36: 44 experimental structures on GenesisL1, 3 ligands bound, 15 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9UQF2
- Protein
- SH3 domain of JNK-interacting Protein 1 (JIP1)
- EC
- 3.1.3.36
- Experimental structures
- 44
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 15 · 4 records with a druggable one
Structures
44 records of Q9UQF2 in the MolNFT archive: 44 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G01 | Pyrazoloquinolones as Novel, Selective JNK1 inhibitors | x-ray diffraction | F, G | — | — |
| 2G01 | Pyrazoloquinolones as novel, selective JNK1 inhibitors | x-ray diffraction | F, G | — | — |
| 2GMX | Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity | x-ray diffraction | F, G | — | — |
| 2GMX | Selective aminopyridine-based C-jun N-terminal kinase inhibitors with cellular activity | x-ray diffraction | F, G | — | — |
| 2H96 | Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun… | x-ray diffraction | F, G | — | — |
| 2H96 | Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide C-jun… | x-ray diffraction | F, G | — | — |
| 3PTG | Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor | x-ray diffraction | J | — | — |
| 3PTG | Design and synthesis of a novel, orally efficacious tri-substituted thiophene based jnk inhibitor | x-ray diffraction | J | — | — |
| 3VUD | Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUD | Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUG | Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUG | Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUH | Crystal structure of a cysteine-deficient mutant M3 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUH | Crystal structure of a cysteine-deficient mutant M3 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUI | Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUI | Crystal structure of a cysteine-deficient mutant M2 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUK | Crystal structure of a cysteine-deficient mutant M5 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUK | Crystal structure of a cysteine-deficient mutant M5 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUL | Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUL | Crystal structure of a cysteine-deficient mutant M1 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUM | Crystal structure of a cysteine-deficient mutant M7 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 3VUM | Crystal structure of a cysteine-deficient mutant M7 in MAP kinase JNK1 | x-ray diffraction | F | — | — |
| 4E73 | Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor | x-ray diffraction | B | — | — |
| 4E73 | Crystal structure of JNK1BETA-jip in complex with an azaquinolone inhbitor | x-ray diffraction | B | — | — |
| 4G1W | Crystal structure of JNK1 in complex with JIP1 peptide and… | x-ray diffraction | B | — | — |
| 4G1W | Crystal structure of JNK1 in complex with JIP1 peptide and 7-fluoro-3… | x-ray diffraction | B | — | — |
| 4H39 | Crystal Structure of JNK3 in Complex with JIP1 Peptide | x-ray diffraction | B | — | — |
| 4H39 | Crystal structure of JNK3 in complex with JIP1 peptide | x-ray diffraction | B | — | — |
| 4HYS | Crystal structure of JNK1 in complex with JIP1 peptide and… | x-ray diffraction | B | — | — |
| 4HYS | Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4… | x-ray diffraction | B | — | — |
| 4HYU | Crystal structure of JNK1 in complex with JIP1 peptide and… | x-ray diffraction | B | — | — |
| 4HYU | Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(3… | x-ray diffraction | B | — | — |
| 4IZY | Crystal structure of JNK1 in complex with JIP1 peptide and… | x-ray diffraction | B | — | — |
| 4IZY | Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(4… | x-ray diffraction | B | — | — |
| 5LW1 | Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1… | x-ray diffraction | C, F, I | SO4 | — |
| 5LW1 | Crystal structure of darpin-darpin rigid fusion, variant DD_232_11_D12 in complex JNK1A1 and JIP1… | x-ray diffraction | C, F, I | SO4 | — |
| 7NYK | SH3 domain of JNK-interacting Protein 1 (JIP1) | x-ray diffraction | AAA, BBB, CCC, DDD | — | 1 (best 0.68) |
| 7NYL | Mutant H493A of SH3 domain of JNK-interacting Protein 1 (JIP1) | x-ray diffraction | AAA, BBB | GLC | — |
| 7NYM | Mutant V517A - SH3 domain of JNK-interacting Protein 1 (JIP1) | x-ray diffraction | AAA, BBB, CCC, DDD | SO4, PO4 | 2 (best 0.52) |
| 7NYN | Mutant Y526A of SH3 domain of JNK-interacting Protein 1 (JIP1) | x-ray diffraction | AAA, BBB, CCC, DDD, EEE, FFF, GGG, HHH, III, JJJ, KKK, LLL | PO4, SO4 | 5 (best 0.65) |
| 7NYO | Mutant A541L of SH3 domain of JNK-interacting Protein 1 (JIP1) | x-ray diffraction | AAA, BBB, CCC, DDD | SO4 | 1 (best 0.44) |
| 7NZB | Mutant V517L of the SH3 domain of JNK-interacting protein 1 (JIP1) | x-ray diffraction | AAA, BBB, CCC, DDD, EEE, FFF, GGG, HHH, III, JJJ, KKK, LLL | PO4 | 6 (best 0.62) |
| 8RPP | Crystal structure of the JIP1-JIP2-SH3 heterodimer and the JIP2-JIP2-SH3 homodimer | x-ray diffraction | D | — | — |
| Q9UQF2 | AlphaFold monomer V2.0 prediction for C-jun-amino-terminal kinase- interacting protein 1 (Q9UQF2) | — | — | — |
Ligands
Elsewhere
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