UniProt Q9UNE7
E3 ubiquitin-protein ligase CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (UniProt Q9UNE7), EC 2.3.2.27: 11 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9UNE7
- Protein
- E3 ubiquitin-protein ligase CHIP
- EC
- 2.3.2.27
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 13 · 4 records with a druggable one
Structures
12 records of Q9UNE7 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4KBQ | Structure of the CHIP-TPR domain in complex with the Hsc70 Lid-Tail domains | x-ray diffraction | A, B | — | — |
| 4KBQ | Structure of the chip-tpr domain in complex with the HSC70 lid-tail domains | x-ray diffraction | A, B | — | — |
| 6EFK | Crystal structure of the human chip tpr domain in complex with a 5MER acetylated HSP70 peptide | x-ray diffraction | A, B | ACE, NA | — |
| 6NSV | Crystal structure of the human CHIP TPR domain in complex with a 5mer acetylated optimized peptide | x-ray diffraction | A, B | CL, NA | 2 (best 0.81) |
| 6NSV | Crystal structure of the human chip tpr domain in complex with a 5MER acetylated optimized peptide | x-ray diffraction | A, B | ACE, CL, NA | — |
| 7TB1 | Crystal structure of STUB1 with a macrocyclic peptide | x-ray diffraction | A, B | I1J | — |
| 8EHZ | Crystal structure of the STUB1 TPR domain in complex with H317, a Helicon Polypeptide | x-ray diffraction | A, B | WHL | 2 (best 0.60) |
| 8EI0 | Crystal structure of the STUB1 TPR domain in complex with H318, a Helicon Polypeptide | x-ray diffraction | A | SO4, WHL | — |
| 8F14 | Structure of the STUB1 TPR domain in complex with H201, an all-D Helicon Polypeptide | x-ray diffraction | A | SO4, WHL | — |
| 8GCK | Crystal structure of the human CHIP-TPR domain in complex with a 6mer acetylated tau peptide | x-ray diffraction | B, A | — | 1 (best 0.82) |
| 8SUV | CHIP-TPR in complex with the C-terminus of CHIC2 | x-ray diffraction | A, B, C, D | SO4 | 8 (best 0.80) |
| Q9UNE7 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase chip (Q9UNE7) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6NSV chain B against the predicted model Q9UNE7: TM-score 0.99, RMSD 0.36 Å
- 6NSV chain B against the predicted model Q9UNE7: TM-score 0.99, RMSD 0.36 Å
- 6NSV chain A against the predicted model Q9UNE7: TM-score 0.99, RMSD 0.40 Å
- 6NSV chain A against the predicted model Q9UNE7: TM-score 0.99, RMSD 0.40 Å
- 8GCK chain A against the predicted model Q9UNE7: TM-score 0.99, RMSD 0.49 Å
- 8F14 chain A against the predicted model Q9UNE7: TM-score 0.98, RMSD 0.57 Å
- 4KBQ chain A against the predicted model Q9UNE7: TM-score 0.98, RMSD 0.60 Å
- 4KBQ chain A against the predicted model Q9UNE7: TM-score 0.98, RMSD 0.60 Å
- 8GCK chain B against the predicted model Q9UNE7: TM-score 0.98, RMSD 0.57 Å
- 8SUV chain A against the predicted model Q9UNE7: TM-score 0.98, RMSD 0.58 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.