UniProt Q9UKF6
Cleavage and polyadenylation specificity factor subunit 3 (Q9UKF6)
Cleavage and polyadenylation specificity factor subunit 3 (UniProt Q9UKF6), EC 3.1.27.-: 9 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 14 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9UKF6
- Protein
- Cleavage and polyadenylation specificity factor subunit 3
- EC
- 3.1.27.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 14 · 2 records with a druggable one
Structures
10 records of Q9UKF6 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I7T | Structure of human CPSF-73 | x-ray diffraction | A | — | — |
| 2I7T | Structure of human cpsf-73 | x-ray diffraction | A | — | — |
| 2I7V | Structure of Human CPSF-73 | x-ray diffraction | A | — | — |
| 2I7V | Structure of human cpsf-73 | x-ray diffraction | A | — | — |
| 6M8Q | Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in complex with NVP-LTM531 | x-ray diffraction | A, B | ZN, JBG, PO4 | — |
| 6M8Q | Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) in complex with nvp-LTM531 | x-ray diffraction | A, B | ZN, JBG, PO4 | — |
| 6V4X | Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 Angstrom… | electron microscopy | H | ZN | 12 (best 0.77) |
| 6V4X | Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 ångström… | electron microscopy | H | ZN | — |
| 8T1R | Crystal structure of human CPSF73 catalytic segment in complex with compound 2 | x-ray diffraction | A | XZC, FE, SO4, CL | 2 (best 0.81) |
| Q9UKF6 | AlphaFold monomer V2.0 prediction for cleavage and polyadenylation specificity factor subunit 3… | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 4 records
- JBG · N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzene-1-carbonyl}-L-phenylalanine · in 2 records
- PO4 · Phosphate ion · in 2 records
- CL · Chloride ion · in 1 record
- FE · Fe (III) ion · in 1 record
- SO4 · Sulfate ion · in 1 record
- XZC · 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(3-methoxyphenyl)phenyl]propanamide · in 1 record
Experiment against prediction
- 6M8Q chain A against the predicted model Q9UKF6: TM-score 1.00, RMSD 0.51 Å
- 6M8Q chain A against the predicted model Q9UKF6: TM-score 1.00, RMSD 0.51 Å
- 6M8Q chain B against the predicted model Q9UKF6: TM-score 1.00, RMSD 0.54 Å
- 6M8Q chain B against the predicted model Q9UKF6: TM-score 1.00, RMSD 0.54 Å
- 2I7V chain A against the predicted model Q9UKF6: TM-score 0.99, RMSD 0.93 Å
- 2I7V chain A against the predicted model Q9UKF6: TM-score 0.99, RMSD 0.93 Å
- 2I7T chain A against the predicted model Q9UKF6: TM-score 0.98, RMSD 1.08 Å
- 2I7T chain A against the predicted model Q9UKF6: TM-score 0.98, RMSD 1.08 Å
- 8T1R chain A against the predicted model Q9UKF6: TM-score 0.97, RMSD 0.88 Å
- 6V4X chain H against the predicted model Q9UKF6: TM-score 0.91, RMSD 2.68 Å
Elsewhere
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