UniProt Q9UKE5
TRAF2 and NCK-interacting protein kinase (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (UniProt Q9UKE5), EC 2.7.11.1: 15 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 48 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9UKE5
- Protein
- TRAF2 and NCK-interacting protein kinase
- EC
- 2.7.11.1
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 48 · 8 records with a druggable one
Structures
16 records of Q9UKE5 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2X7F | Crystal structure of the kinase domain of human Traf2- and Nck- interacting Kinase with Wee1Chk1… | x-ray diffraction | A, B, C, D, E | 824, NA | 18 (best 0.79) |
| 2X7F | Crystal structure of the kinase domain of human TRAF2- and nck- interacting kinase with WEE1CHK1… | x-ray diffraction | A, B, C, D, E | — | — |
| 5AX9 | Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase in complex… | x-ray diffraction | A, B, C | — | — |
| 5AX9 | Crystal structure of the kinase domain of human TRAF2 and nck- interacting protein kinase in… | x-ray diffraction | A, B, C | — | — |
| 5CWZ | Crystal structure of the kinase domain of human TRAF2 and NCK-interacting protein kinase | x-ray diffraction | A, B, C | — | 8 (best 0.77) |
| 5CWZ | Crystal structure of the kinase domain of human TRAF2 and nck- interacting protein kinase | x-ray diffraction | A, B, C | — | — |
| 5D7A | Crystal structure of the kinase domain of TRAF2 and nck-interacting protein kinase with ncb-0846 | x-ray diffraction | A, B, C | — | — |
| 6RA5 | Human tnik in complex with compound 9 | x-ray diffraction | A, B | JWE, MG | 5 (best 0.70) |
| 6RA5 | Human tnik in complex with compound 9 | x-ray diffraction | A, B | JWE, MG | — |
| 6RA7 | Human tnik in complex with compound 9 | x-ray diffraction | A | MG, JWK | 1 (best 0.66) |
| 6RA7 | Human tnik in complex with compound 9 | x-ray diffraction | A | MG, JWK | — |
| 7XZQ | Crystal structure of TNIK-thiopeptide TP1 complex | x-ray diffraction | A | — | 2 (best 0.73) |
| 7XZR | Crystal structure of TNIK-AMPPNP-thiopeptide TP15 complex | x-ray diffraction | A, B | ANP, MG, SO4 | — |
| 8WM0 | Crystal structure of TNIK-thiopeptide wTP3 complex | x-ray diffraction | A | ADN | 2 (best 0.70) |
| 8X88 | The Crystal Structure of TNIK from Biortus. | x-ray diffraction | A, B | — | 3 (best 0.82) |
| Q9UKE5 | AlphaFold monomer V2.0 prediction for TRAF2 and nck-interacting protein kinase (Q9UKE5) | predicted | A | — | 9 (best 0.73) |
Ligands
- MG · Magnesium ion · in 5 records
- JWE · 5-bromanyl-2-(2-fluoranylpyridin-4-yl)-1,7-naphthyridin-8-amine · in 2 records
- JWK · 2-[8-azanyl-2-(2-fluoranylpyridin-4-yl)-1,7-naphthyridin-5-yl]propan-2-ol · in 2 records
- 824 · 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione · in 1 record
- ADN · Adenosine · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- NA · Sodium ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 2X7F chain E against the predicted model Q9UKE5: TM-score 0.99, RMSD 0.69 Å
- 2X7F chain E against the predicted model Q9UKE5: TM-score 0.99, RMSD 0.69 Å
- 2X7F chain D against the predicted model Q9UKE5: TM-score 0.98, RMSD 0.82 Å
- 2X7F chain D against the predicted model Q9UKE5: TM-score 0.98, RMSD 0.82 Å
- 2X7F chain C against the predicted model Q9UKE5: TM-score 0.98, RMSD 0.95 Å
- 2X7F chain C against the predicted model Q9UKE5: TM-score 0.98, RMSD 0.95 Å
- 2X7F chain A against the predicted model Q9UKE5: TM-score 0.98, RMSD 0.98 Å
- 2X7F chain A against the predicted model Q9UKE5: TM-score 0.98, RMSD 0.98 Å
- 2X7F chain B against the predicted model Q9UKE5: TM-score 0.98, RMSD 1.07 Å
- 2X7F chain B against the predicted model Q9UKE5: TM-score 0.98, RMSD 1.07 Å
Elsewhere
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