UniProt Q9UJA3
DNA helicase MCM8 (Q9UJA3)
DNA helicase MCM8 (UniProt Q9UJA3), EC 3.6.4.12: 9 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 94 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UJA3
- Protein
- DNA helicase MCM8
- EC
- 3.6.4.12
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 94 · 7 records with a druggable one
Structures
10 records of Q9UJA3 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6L0O | WH domain of human MCM8 | x-ray diffraction | A | SO4 | — |
| 6L0O | Wh domain of human MCM8 | x-ray diffraction | A | SO4 | — |
| 7DP3 | Human MCM8 N-terminal domain | x-ray diffraction | A, B | ZN | 8 (best 0.76) |
| 7DP3 | Human MCM8 N-terminal domain | x-ray diffraction | A, B | ZN | — |
| 7WI7 | Crystal structure of human MCM8/9 complex | x-ray diffraction | A | ZN | 8 (best 0.81) |
| 7YOX | Cryo-EM structure of the N-terminal domain of hMCM8/9 and HROB | electron microscopy | A, C, F | — | 18 (best 0.78) |
| 8S91 | Structure of Walker B mutated MCM8/9 heterohexamer complex with ADP | electron microscopy | A, B, C | ADP, MG | 18 (best 0.85) |
| 8S92 | Structure of N-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP | electron microscopy | A, B, C | — | 19 (best 0.74) |
| 8S94 | Structure of C-terminal domains of Walker B mutated MCM8/9 heterohexamer complex with ADP | electron microscopy | A, C, B | ADP, MG | 14 (best 0.85) |
| Q9UJA3 | AlphaFold monomer V2.0 prediction for DNA helicase MCM8 (Q9UJA3) | predicted | A | — | 9 (best 0.74) |
Ligands
Experiment against prediction
- 8S94 chain C against the predicted model Q9UJA3: TM-score 0.96, RMSD 1.51 Å
- 8S94 chain B against the predicted model Q9UJA3: TM-score 0.96, RMSD 1.51 Å
- 8S94 chain A against the predicted model Q9UJA3: TM-score 0.96, RMSD 1.51 Å
- 8S92 chain B against the predicted model Q9UJA3: TM-score 0.91, RMSD 2.13 Å
- 8S92 chain A against the predicted model Q9UJA3: TM-score 0.91, RMSD 2.13 Å
- 8S92 chain C against the predicted model Q9UJA3: TM-score 0.91, RMSD 2.14 Å
- 6L0O chain A against the predicted model Q9UJA3: TM-score 0.90, RMSD 0.80 Å
- 6L0O chain A against the predicted model Q9UJA3: TM-score 0.90, RMSD 0.80 Å
- 7WI7 chain A against the predicted model Q9UJA3: TM-score 0.90, RMSD 3.15 Å
- 7YOX chain C against the predicted model Q9UJA3: TM-score 0.88, RMSD 2.73 Å
Elsewhere
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