UniProt Q9UIS9
Methyl-CpG-binding domain protein 1 (Q9UIS9)
Methyl-CpG-binding domain protein 1 (UniProt Q9UIS9): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UIS9
- Protein
- Methyl-CpG-binding domain protein 1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 10 · 2 records with a druggable one
Structures
11 records of Q9UIS9 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D9N | Solution structure of the methyl-cpg-binding domain of the methylation-dependent transcriptional… | solution nmr | A | — | — |
| 1D9N | Solution structure of the methyl-cpg-binding domain of the methylation-dependent transcriptional… | solution nmr | A | — | — |
| 1IG4 | Solution Structure of the Methyl-CpG-Binding Domain of Human MBD1 in Complex with Methylated DNA | solution nmr | A | — | — |
| 1IG4 | Solution structure of the methyl-cpg-binding domain of human MBD1 in complex with methylated DNA | solution nmr | A | — | — |
| 4D4W | Solution structure of human MBD1 CXXC1 domain | solution nmr | A | — | — |
| 4D4W | Solution structure of human MBD1 CXXC1 domain | solution nmr | A | — | — |
| 5W9Q | Zinc finger region of MBD1 in complex with CpG DNA | x-ray diffraction | A, B | ZN, UNX | 4 (best 0.41) |
| 5W9Q | Zinc finger region of MBD1 in complex with cpg DNA | x-ray diffraction | A, B | ZN, UNX | — |
| 6D1T | Complex of MBD1-MBD and methylated DNA | x-ray diffraction | A | UNX | 2 (best 0.63) |
| 6D1T | Complex of MBD1-mbd and methylated DNA | x-ray diffraction | A | UNX | — |
| Q9UIS9 | AlphaFold monomer V2.0 prediction for methyl-cpg-binding domain protein 1 (Q9UIS9) | predicted | A | — | 4 (best 0.60) |
Ligands
Experiment against prediction
- 6D1T chain A against the predicted model Q9UIS9: TM-score 0.97, RMSD 0.51 Å
- 6D1T chain A against the predicted model Q9UIS9: TM-score 0.97, RMSD 0.51 Å
- 5W9Q chain B against the predicted model Q9UIS9: TM-score 0.93, RMSD 0.73 Å
- 5W9Q chain B against the predicted model Q9UIS9: TM-score 0.93, RMSD 0.73 Å
- 5W9Q chain A against the predicted model Q9UIS9: TM-score 0.92, RMSD 0.97 Å
- 5W9Q chain A against the predicted model Q9UIS9: TM-score 0.92, RMSD 0.97 Å
- 1IG4 chain A against the predicted model Q9UIS9: TM-score 0.78, RMSD 1.76 Å
- 1IG4 chain A against the predicted model Q9UIS9: TM-score 0.78, RMSD 1.76 Å
- 1D9N chain A against the predicted model Q9UIS9: TM-score 0.61, RMSD 2.55 Å
- 1D9N chain A against the predicted model Q9UIS9: TM-score 0.61, RMSD 2.55 Å
Elsewhere
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