UniProt Q9UBU3
Appetite-regulating hormone (Q9UBU3)
Appetite-regulating hormone (UniProt Q9UBU3): 7 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UBU3
- Protein
- Appetite-regulating hormone
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 4 · 2 records with a druggable one
Structures
8 records of Q9UBU3 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6H3E | Receptor-bound Ghrelin conformation | solution nmr | A | FKZ | — |
| 6H3E | Receptor-bound ghrelin conformation | solution nmr | A | NH2, FKZ | — |
| 7F9Y | Ghrelin-bound ghrelin receptor in complex with gq | electron microscopy | C | OCA | — |
| 7NA7 | Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist | electron microscopy | L | — | 2 (best 0.52) |
| 7NA7 | Structures of human ghrelin receptor-gi complexes with ghrelin and a synthetic agonist | electron microscopy | L | — | — |
| 7W2Z | Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex | electron microscopy | L | — | 2 (best 0.81) |
| 7W2Z | Cryo-EM structure of the ghrelin-bound human ghrelin receptor-go complex | electron microscopy | L | K4Q | — |
| Q9UBU3 | AlphaFold monomer V2.0 prediction for appetite-regulating hormone (Q9UBU3) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7W2Z chain L against the predicted model Q9UBU3: TM-score 0.40, RMSD 0.57 Å
- 7W2Z chain L against the predicted model Q9UBU3: TM-score 0.40, RMSD 0.57 Å
- 7F9Y chain C against the predicted model Q9UBU3: TM-score 0.29, RMSD 1.77 Å
- 7NA7 chain L against the predicted model Q9UBU3: TM-score 0.27, RMSD 1.88 Å
- 7NA7 chain L against the predicted model Q9UBU3: TM-score 0.27, RMSD 1.88 Å
- 6H3E chain A against the predicted model Q9UBU3: TM-score 0.14, RMSD 1.78 Å
- 6H3E chain A against the predicted model Q9UBU3: TM-score 0.14, RMSD 1.78 Å
Elsewhere
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