UniProt Q9UBQ5
Eukaryotic translation initiation factor 3 subunit K (Q9UBQ5)
Eukaryotic translation initiation factor 3 subunit K (UniProt Q9UBQ5): 12 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UBQ5
- Protein
- Eukaryotic translation initiation factor 3 subunit K
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 10 · 6 records with a druggable one
Structures
13 records of Q9UBQ5 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RZ4 | Crystal Structure of Human eIF3k | x-ray diffraction | A | — | — |
| 1RZ4 | Crystal structure of human EIF3K | x-ray diffraction | A | — | — |
| 6YBD | Structure of a human 48S translational initiation complex - EIF3 | electron microscopy | 3 | — | — |
| 6ZON | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | electron microscopy | K | — | 1 (best 0.83) |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | K | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | 3 | — | — |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | 3 | — | — |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | 3 | — | 2 (best 0.85) |
| 8PJ6 | Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3… | electron microscopy | 3 | — | 1 (best 0.85) |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | I3 | — | 2 (best 0.86) |
| 8RG0 | Structure of human eIF3 core from closed 48S translation initiation complex | electron microscopy | 3 | — | 3 (best 0.87) |
| 8XXN | Cryo-EM structure of the human 43S ribosome with PDCD4 | electron microscopy | 3K | — | 1 (best 0.82) |
| Q9UBQ5 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit K (Q9UBQ5) | predicted | A | — | — |
Experiment against prediction
- 8XXN chain 3K against the predicted model Q9UBQ5: TM-score 0.88, RMSD 2.29 Å
- 8PPL chain I3 against the predicted model Q9UBQ5: TM-score 0.88, RMSD 2.03 Å
- 7A09 chain K against the predicted model Q9UBQ5: TM-score 0.88, RMSD 2.39 Å
- 6ZON chain K against the predicted model Q9UBQ5: TM-score 0.88, RMSD 2.38 Å
- 1RZ4 chain A against the predicted model Q9UBQ5: TM-score 0.87, RMSD 1.51 Å
- 1RZ4 chain A against the predicted model Q9UBQ5: TM-score 0.87, RMSD 1.51 Å
- 6YBD chain 3 against the predicted model Q9UBQ5: TM-score 0.85, RMSD 2.51 Å
- 8RG0 chain 3 against the predicted model Q9UBQ5: TM-score 0.83, RMSD 2.62 Å
- 8PJ1 chain 3 against the predicted model Q9UBQ5: TM-score 0.81, RMSD 2.89 Å
- 8PJ6 chain 3 against the predicted model Q9UBQ5: TM-score 0.79, RMSD 2.91 Å
Elsewhere
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