UniProt Q9SU72
Protein EDS1 (Q9SU72)
Protein EDS1 (UniProt Q9SU72): 10 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 84 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9SU72
- Protein
- Protein EDS1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 84 · 7 records with a druggable one
Structures
11 records of Q9SU72 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7XDD | Cryo-EM structure of EDS1 and PAD4 | electron microscopy | B | — | 9 (best 0.75) |
| 7XDD | Cryo-EM structure of EDS1 and PAD4 | electron microscopy | B | — | — |
| 7XEY | EDS1-PAD4 complexed with pRib-ADP | x-ray diffraction | A | ADP, RP5 | 10 (best 0.83) |
| 7XEY | EDS1-PAD4 complexed with prib-ADP | x-ray diffraction | A | ADP, RP5 | — |
| 7XJP | Cryo-EM structure of EDS1 and SAG101 with ATP-APDR | electron microscopy | A | APR, ATP | 13 (best 0.82) |
| 7XJP | Cryo-EM structure of EDS1 and SAG101 with ATP-apdr | electron microscopy | A | APR, ATP | — |
| 8YN0 | Crystal structure of NRG1C in complex with EDS1-SAG101-(ADPr-ATP) | x-ray diffraction | B, A | APR, ATP | 14 (best 0.85) |
| 8YN1 | Cryo-EM structure of NRG1A(LRR) in complex with EDS1-SAG101-(ADPr-ATP) | electron microscopy | A | APR, ATP | 13 (best 0.86) |
| 8ZW9 | RPS4-TIR induced At EDS1-PAD4-ADR1 heterotrimer | electron microscopy | B | A1D8A | 13 (best 0.82) |
| 8ZWA | HopBY induced At EDS1-PAD4-ADR1 heterotrimer | electron microscopy | B | RIA | 12 (best 0.84) |
| Q9SU72 | AlphaFold monomer V2.0 prediction for protein EDS1 (Q9SU72) | predicted | A | — | — |
Ligands
- APR · Adenosine-5-diphosphoribose · in 4 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- RP5 · 5-O-phosphono-beta-D-ribofuranose · in 2 records
- A1D8A · [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[(2S,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate · in 1 record
- RIA · 2'-O-[(5'-phospho)ribosyl]adenosine-5'-monophosphate · in 1 record
Experiment against prediction
- 7XDD chain B against the predicted model Q9SU72: TM-score 0.99, RMSD 0.75 Å
- 7XDD chain B against the predicted model Q9SU72: TM-score 0.99, RMSD 0.75 Å
- 7XEY chain A against the predicted model Q9SU72: TM-score 0.99, RMSD 0.82 Å
- 7XEY chain A against the predicted model Q9SU72: TM-score 0.99, RMSD 0.82 Å
- 8YN0 chain B against the predicted model Q9SU72: TM-score 0.99, RMSD 0.83 Å
- 8YN0 chain A against the predicted model Q9SU72: TM-score 0.99, RMSD 0.85 Å
- 7XJP chain A against the predicted model Q9SU72: TM-score 0.99, RMSD 0.97 Å
- 7XJP chain A against the predicted model Q9SU72: TM-score 0.99, RMSD 0.97 Å
- 8YN1 chain A against the predicted model Q9SU72: TM-score 0.98, RMSD 1.09 Å
- 8ZW9 chain B against the predicted model Q9SU72: TM-score 0.98, RMSD 1.13 Å
Elsewhere
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