UniProt Q9R0M5
thiamin pyrophosphokinase (Q9R0M5)
thiamin pyrophosphokinase (UniProt Q9R0M5), EC 2.7.6.2: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9R0M5
- Protein
- thiamin pyrophosphokinase
- EC
- 2.7.6.2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 2 records with a druggable one
Structures
5 records of Q9R0M5 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IG3 | Mouse Thiamin Pyrophosphokinase Complexed with Thiamin | x-ray diffraction | A, B | SO4, VIB | 4 (best 0.67) |
| 1IG3 | Mouse thiamin pyrophosphokinase complexed with thiamin | x-ray diffraction | A, B | — | — |
| 2F17 | Mouse Thiamin Pyrophosphokinase in a Ternary Complex with Pyrithiamin Pyrophosphate and AMP at 2.5… | x-ray diffraction | A, B | — | — |
| 2F17 | Mouse thiamin pyrophosphokinase in a ternary complex with pyrithiamin pyrophosphate and AMP at 2.5… | x-ray diffraction | A, B | — | — |
| Q9R0M5 | AlphaFold monomer V2.0 prediction for thiamin pyrophosphokinase 1 (Q9R0M5) | predicted | A | — | 3 (best 0.55) |
Ligands
Experiment against prediction
- 1IG3 chain A against the predicted model Q9R0M5: TM-score 0.95, RMSD 0.60 Å
- 1IG3 chain A against the predicted model Q9R0M5: TM-score 0.95, RMSD 0.60 Å
- 2F17 chain A against the predicted model Q9R0M5: TM-score 0.94, RMSD 0.60 Å
- 2F17 chain A against the predicted model Q9R0M5: TM-score 0.94, RMSD 0.60 Å
- 2F17 chain B against the predicted model Q9R0M5: TM-score 0.99, RMSD 0.61 Å
- 2F17 chain B against the predicted model Q9R0M5: TM-score 0.99, RMSD 0.61 Å
- 1IG3 chain B against the predicted model Q9R0M5: TM-score 0.99, RMSD 0.67 Å
- 1IG3 chain B against the predicted model Q9R0M5: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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