UniProt Q9P1Z3
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Q9P1Z3)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (UniProt Q9P1Z3): 3 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 60 pockets. Binding sites, druggability and…
- UniProt
- Q9P1Z3
- Protein
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 60 · 3 records with a druggable one
Structures
4 records of Q9P1Z3 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8INZ | Cryo-EM structure of human HCN3 channel in apo state | electron microscopy | C, A, B, D | VX9 | 20 (best 0.83) |
| 8IO0 | Cryo-EM structure of human HCN3 channel with cAMP | electron microscopy | A, B, C, D | CMP | 20 (best 0.84) |
| 8IO3 | Cryo-EM structure of human HCN3 channel with cilobradine | electron microscopy | C, A, B, D | VXI | 20 (best 0.85) |
| Q9P1Z3 | AlphaFold monomer V2.0 prediction for POTASSIUM/SODIUM hyperpolarization-activated cyclic… | predicted | A | — | — |
Ligands
- CMP · Adenosine-3',5'-cyclic-monophosphate · in 1 record
- VX9 · 4-[[(2~{S},4~{a}~{R},6~{S},8~{a}~{S})-6-[(4~{S},5~{R})-4-[(2~{S})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{H}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid · in 1 record
- VXI · 3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one · in 1 record
Experiment against prediction
- 8IO0 chain A against the predicted model Q9P1Z3: TM-score 0.95, RMSD 1.77 Å
- 8IO0 chain C against the predicted model Q9P1Z3: TM-score 0.95, RMSD 1.77 Å
- 8IO0 chain B against the predicted model Q9P1Z3: TM-score 0.95, RMSD 1.77 Å
- 8IO0 chain D against the predicted model Q9P1Z3: TM-score 0.95, RMSD 1.77 Å
- 8IO3 chain A against the predicted model Q9P1Z3: TM-score 0.94, RMSD 1.89 Å
- 8IO3 chain B against the predicted model Q9P1Z3: TM-score 0.94, RMSD 1.89 Å
- 8IO3 chain C against the predicted model Q9P1Z3: TM-score 0.94, RMSD 1.89 Å
- 8IO3 chain D against the predicted model Q9P1Z3: TM-score 0.94, RMSD 1.89 Å
- 8INZ chain C against the predicted model Q9P1Z3: TM-score 0.93, RMSD 2.28 Å
- 8INZ chain B against the predicted model Q9P1Z3: TM-score 0.93, RMSD 2.28 Å
Elsewhere
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