UniProt Q9P086
Mediator of RNA polymerase II transcription subunit 11 (Q9P086)
Mediator of RNA polymerase II transcription subunit 11 (UniProt Q9P086): 14 experimental structures and 1 predicted model on GenesisL1, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9P086
- Protein
- Mediator of RNA polymerase II transcription subunit 11
- Experimental structures
- 14
- Predicted models
- 1
- Pockets
- 8 · 6 records with a druggable one
Structures
15 records of Q9P086 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | K | — | 1 (best 0.73) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | K | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | k | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | k | — | — |
| 7ENJ | Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) | electron microscopy | K | — | 1 (best 0.78) |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | K | — | — |
| 7LBM | Structure of the human Mediator-bound transcription pre-initiation complex | electron microscopy | i | — | 1 (best 0.79) |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | c | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | c | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | k | — | 1 (best 0.81) |
| 8GXS | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | electron microscopy | k | — | — |
| 8T9D | CryoEM structure of TR-TRAP | electron microscopy | H | — | 2 (best 0.84) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | K | — | 2 (best 0.87) |
| 8TRH | The IDRc bound human core Mediator complex | electron microscopy | K | — | — |
| Q9P086 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 11… | predicted | A | — | — |
Experiment against prediction
- 7LBM chain i against the predicted model Q9P086: TM-score 0.59, RMSD 1.95 Å
- 8TRH chain K against the predicted model Q9P086: TM-score 0.58, RMSD 2.31 Å
- 8GXQ chain k against the predicted model Q9P086: TM-score 0.58, RMSD 2.08 Å
- 8GXS chain k against the predicted model Q9P086: TM-score 0.58, RMSD 2.08 Å
- 7ENC chain k against the predicted model Q9P086: TM-score 0.58, RMSD 1.86 Å
- 7EMF chain K against the predicted model Q9P086: TM-score 0.58, RMSD 2.48 Å
- 7EMF chain K against the predicted model Q9P086: TM-score 0.58, RMSD 2.48 Å
- 7ENJ chain K against the predicted model Q9P086: TM-score 0.58, RMSD 2.48 Å
- 7ENJ chain K against the predicted model Q9P086: TM-score 0.58, RMSD 2.48 Å
- 7ENA chain k against the predicted model Q9P086: TM-score 0.58, RMSD 1.38 Å
Elsewhere
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