UniProt Q9NYL2
Mitogen-activated protein kinase kinase kinase MLT (Q9NYL2)
Mitogen-activated protein kinase kinase kinase MLT (UniProt Q9NYL2), EC 2.7.11.25: 10 experimental structures on GenesisL1, 6 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9NYL2
- Protein
- Mitogen-activated protein kinase kinase kinase MLT
- EC
- 2.7.11.25
- Experimental structures
- 10
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 9 · 2 records with a druggable one
Structures
10 records of Q9NYL2 in the MolNFT archive: 10 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5HES | Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK)… | x-ray diffraction | A, B | 032 | — |
| 5HES | Human leucine zipper- and sterile alpha motif-containing kinase (zak, mlt, hccs-4, mrk, azk, mltk)… | x-ray diffraction | A, B | — | — |
| 5X5O | Crystal structure of zak in complex with compound D2829 | x-ray diffraction | A | 7Z0 | — |
| 6JUT | Crystal structure of ZAK in complex with compound 6k | x-ray diffraction | A | C9O | — |
| 6JUT | Crystal structure of zak in complex with compound 6K | x-ray diffraction | A | C9O | — |
| 6JUU | Crystal structure of ZAK in complex with compound 6r | x-ray diffraction | A | C9R | — |
| 6JUU | Crystal structure of zak in complex with compound 6R | x-ray diffraction | A | C9R | — |
| 7YAW | Crystal structure of ZAK in complex with compound YH-180 | x-ray diffraction | D, A, B, C | IGS | 7 (best 0.82) |
| 7YAZ | Crystal structure of ZAK in complex with compound YH-186 | x-ray diffraction | A | IGV | 2 (best 0.76) |
| Q9NYL2 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase kinase kinase 20 (Q9NYL2) | — | — | — |
Ligands
- C9O · ~{N}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{H}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]-3-bromanyl-benzenesulfonamide · in 2 records
- C9R · ~{N}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{H}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]naphthalene-1-sulfonamide · in 2 records
- 032 · N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide · in 1 record
- 7Z0 · N-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamide · in 1 record
- IGS · ~{N}-[3-[[5-[1-[2,6-bis(fluoranyl)-3-[(3-phenylphenyl)sulfonylamino]phenyl]-1,2,3-triazol-4-yl]-1~{H}-pyrazolo[3,4-b]pyridin-3-yl]oxy]propyl]propanamide · in 1 record
- IGV · ~{N}-[2,4-bis(fluoranyl)-3-[4-[3-[(3~{S})-1-propanoylpyrrolidin-3-yl]oxy-1~{H}-pyrazolo[3,4-b]pyridin-5-yl]-1,2,3-triazol-1-yl]phenyl]-3-phenyl-benzenesulfonamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.