UniProt Q9NXF7
DDB1- and CUL4-associated factor 16 (Q9NXF7)
DDB1- and CUL4-associated factor 16 (UniProt Q9NXF7): 2 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NXF7
- Protein
- DDB1- and CUL4-associated factor 16
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 19 · 2 records with a druggable one
Structures
3 records of Q9NXF7 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8G46 | Cryo-EM structure of DDB1deltaB-DDA1-DCAF16-BRD4(BD2)-MMH2 | electron microscopy | B | ZN, YK3 | 8 (best 0.85) |
| 8OV6 | Ternary structure of intramolecular bivalent glue degrader IBG1 bound to BRD4 and… | electron microscopy | B | ZN, U79 | 11 (best 0.85) |
| Q9NXF7 | AlphaFold monomer V2.0 prediction for DDB1- and CUL4-associated factor 16 (Q9NXF7) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 2 records
- U79 · methyl 2-[(9~{S})-7-[4-[4-[[4-[(3-cyano-4-methyl-1~{H}-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoate · in 1 record
- YK3 · tert-butyl [(6S,10P)-4-{4-[(ethanesulfonyl)amino]phenyl}-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate · in 1 record
Experiment against prediction
- 8G46 chain B against the predicted model Q9NXF7: TM-score 0.26, RMSD 6.21 Å
- 8OV6 chain B against the predicted model Q9NXF7: TM-score 0.24, RMSD 4.93 Å
Elsewhere
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