UniProt Q9NX74
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (Q9NX74)
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (UniProt Q9NX74), EC 1.3.1.-: 20 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 5 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9NX74
- Protein
- tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
- EC
- 1.3.1.-
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 5 · 2 records with a druggable one
Structures
21 records of Q9NX74 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WFS | Crystal Structure of tRNA-dihydrouridine(20) synthase catalytic domain | x-ray diffraction | A | — | — |
| 4WFS | Crystal structure of tRNA-DIHYDROURIDINE(20) synthase catalytic domain | x-ray diffraction | A | — | — |
| 4WFT | Crystal structure of tRNA-dihydrouridine(20) synthase dsRBD domain | x-ray diffraction | C, A, B | — | — |
| 4WFT | Crystal structure of tRNA-DIHYDROURIDINE(20) synthase dsrbd domain | x-ray diffraction | C, A, B | — | — |
| 4XP7 | Crystal structure of Human tRNA dihydrouridine synthase 2 | x-ray diffraction | A | — | — |
| 4XP7 | Crystal structure of human tRNA dihydrouridine synthase 2 | x-ray diffraction | A | — | — |
| 5OC4 | Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD R361A-R362A mutant | x-ray diffraction | A | CL | — |
| 5OC4 | Crystal structure of human tRNA-DIHYDROURIDINE(20) synthase dsrbd R361A-R362A mutant | x-ray diffraction | A | CL | — |
| 5OC5 | Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD K419A-K420A mutant | x-ray diffraction | A | CL | — |
| 5OC5 | Crystal structure of human tRNA-DIHYDROURIDINE(20) synthase dsrbd K419A-K420A mutant | x-ray diffraction | A | CL | — |
| 5OC6 | Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD in complex with a 22 nucleotide… | x-ray diffraction | A | — | — |
| 5OC6 | Crystal structure of human tRNA-DIHYDROURIDINE(20) synthase dsrbd in complex with a 22 nucleotide… | x-ray diffraction | A | — | — |
| 6EI8 | Crystal structure of human tRNA-dihydrouridine (20) synthase dsrbd F359A mutant | x-ray diffraction | A | SO4 | — |
| 6EZA | Crystal structure of human tRNA-DIHYDROURIDINE(20) synthase catalytic domain E294K mutant | x-ray diffraction | A, B | FMN, SO4, CL | — |
| 6EZB | Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain Q305K mutant | x-ray diffraction | A | FMN, SO4 | 3 (best 0.56) |
| 6EZB | Crystal structure of human tRNA-DIHYDROURIDINE(20) synthase catalytic domain Q305K mutant | x-ray diffraction | A | FMN, SO4 | — |
| 6EZC | Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain E294K Q305K double… | x-ray diffraction | A | FMN, SO4, CL | — |
| 6EZC | Crystal structure of human tRNA-DIHYDROURIDINE(20) synthase catalytic domain E294K Q305K double… | x-ray diffraction | A | FMN, SO4, CL | — |
| 6F00 | Crystal Structure of human tRNA dihydrouridine synthase (20) dsRBD E423A mutant | x-ray diffraction | B, A, C | SO4 | 2 (best 0.54) |
| 6F00 | Crystal structure of human tRNA dihydrouridine synthase (20) dsrbd E423A mutant | x-ray diffraction | B, A, C | SO4 | — |
| Q9NX74 | AlphaFold monomer V2.0 prediction for tRNA-DIHYDROURIDINE(20) synthase [NAD(P)+]-like (Q9NX74) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4WFS chain A against the predicted model Q9NX74: TM-score 1.00, RMSD 0.38 Å
- 4WFS chain A against the predicted model Q9NX74: TM-score 1.00, RMSD 0.38 Å
- 6EZC chain A against the predicted model Q9NX74: TM-score 1.00, RMSD 0.58 Å
- 6EZC chain A against the predicted model Q9NX74: TM-score 1.00, RMSD 0.58 Å
- 6EZA chain B against the predicted model Q9NX74: TM-score 0.99, RMSD 0.59 Å
- 6EZA chain A against the predicted model Q9NX74: TM-score 0.99, RMSD 0.59 Å
- 6EZB chain A against the predicted model Q9NX74: TM-score 0.99, RMSD 0.62 Å
- 6EZB chain A against the predicted model Q9NX74: TM-score 0.99, RMSD 0.62 Å
- 4XP7 chain A against the predicted model Q9NX74: TM-score 0.99, RMSD 0.83 Å
- 4XP7 chain A against the predicted model Q9NX74: TM-score 0.99, RMSD 0.83 Å
Elsewhere
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