UniProt Q9NX70
Mediator of RNA polymerase II transcription subunit 29 (Q9NX70)
Mediator of RNA polymerase II transcription subunit 29 (UniProt Q9NX70): 12 experimental structures and 1 predicted model on GenesisL1, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NX70
- Protein
- Mediator of RNA polymerase II transcription subunit 29
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 14 · 7 records with a druggable one
Structures
13 records of Q9NX70 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | 2 | — | 3 (best 0.77) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | 2 | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | b | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | b | — | — |
| 7ENJ | Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) | electron microscopy | 2 | — | 2 (best 0.79) |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | 2 | — | — |
| 7LBM | Structure of the human Mediator-bound transcription pre-initiation complex | electron microscopy | p | — | 1 (best 0.79) |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | b | — | — |
| 8GXS | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | electron microscopy | b | — | 1 (best 0.81) |
| 8T9D | CryoEM structure of TR-TRAP | electron microscopy | X | — | 3 (best 0.89) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | 2 | — | 2 (best 0.88) |
| 8TRH | The IDRc bound human core Mediator complex | electron microscopy | 2 | — | 2 (best 0.79) |
| Q9NX70 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 29… | predicted | A | — | — |
Experiment against prediction
- 7LBM chain p against the predicted model Q9NX70: TM-score 0.72, RMSD 2.27 Å
- 8GXS chain b against the predicted model Q9NX70: TM-score 0.72, RMSD 2.33 Å
- 8GXQ chain b against the predicted model Q9NX70: TM-score 0.72, RMSD 2.33 Å
- 7ENC chain b against the predicted model Q9NX70: TM-score 0.72, RMSD 2.35 Å
- 7ENA chain b against the predicted model Q9NX70: TM-score 0.72, RMSD 2.35 Å
- 7ENJ chain 2 against the predicted model Q9NX70: TM-score 0.72, RMSD 2.16 Å
- 7ENJ chain 2 against the predicted model Q9NX70: TM-score 0.72, RMSD 2.16 Å
- 7EMF chain 2 against the predicted model Q9NX70: TM-score 0.72, RMSD 2.16 Å
- 7EMF chain 2 against the predicted model Q9NX70: TM-score 0.72, RMSD 2.16 Å
- 8T9D chain X against the predicted model Q9NX70: TM-score 0.71, RMSD 2.50 Å
Elsewhere
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