UniProt Q9NQW8
Cyclic nucleotide-gated cation channel beta-3 (Q9NQW8)
Cyclic nucleotide-gated cation channel beta-3 (UniProt Q9NQW8): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 81 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9NQW8
- Protein
- Cyclic nucleotide-gated cation channel beta-3
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 81 · 8 records with a druggable one
Structures
11 records of Q9NQW8 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7RHS | Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel | electron microscopy | D | NA | 13 (best 0.80) |
| 7RHS | Cryo-EM structure of apo-state of human CNGA3/CNGB3 channel | electron microscopy | D | NA | — |
| 8ETP | Cryo-EM structure of cGMP bound closed state of human CNGA3/CNGB3 channel in GDN | electron microscopy | D | PCG | 9 (best 0.77) |
| 8EU3 | Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 1 | electron microscopy | D | PCG | — |
| 8EUC | Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 2 | electron microscopy | D | PCG | 8 (best 0.79) |
| 8EV8 | Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, closed state | electron microscopy | D | PCG | 11 (best 0.80) |
| 8EV9 | Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition… | electron microscopy | D | PCG | 10 (best 0.77) |
| 8EVA | Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, transition… | electron microscopy | D | PCG | 10 (best 0.79) |
| 8EVB | Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, pre-open… | electron microscopy | D | PCG | 11 (best 0.80) |
| 8EVC | Cryo-EM structure of cGMP bound truncated human CNGA3/CNGB3 channel in lipid nanodisc, open state | electron microscopy | D | PCG | 9 (best 0.82) |
| Q9NQW8 | AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated cation channel beta-3 (Q9NQW8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8EVB chain D against the predicted model Q9NQW8: TM-score 0.97, RMSD 1.25 Å
- 8EVA chain D against the predicted model Q9NQW8: TM-score 0.97, RMSD 1.46 Å
- 8EUC chain D against the predicted model Q9NQW8: TM-score 0.96, RMSD 1.54 Å
- 8EVC chain D against the predicted model Q9NQW8: TM-score 0.96, RMSD 1.58 Å
- 8EV9 chain D against the predicted model Q9NQW8: TM-score 0.94, RMSD 1.84 Å
- 8EU3 chain D against the predicted model Q9NQW8: TM-score 0.94, RMSD 1.92 Å
- 7RHS chain D against the predicted model Q9NQW8: TM-score 0.92, RMSD 2.36 Å
- 7RHS chain D against the predicted model Q9NQW8: TM-score 0.92, RMSD 2.36 Å
- 8EV8 chain D against the predicted model Q9NQW8: TM-score 0.92, RMSD 2.49 Å
- 8ETP chain D against the predicted model Q9NQW8: TM-score 0.91, RMSD 2.42 Å
Elsewhere
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