UniProt Q9NQV7
Histone-lysine N-methyltransferase PRDM9 (Q9NQV7)
Histone-lysine N-methyltransferase PRDM9 (UniProt Q9NQV7), EC 2.1.1.43: 10 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9NQV7
- Protein
- Histone-lysine N-methyltransferase PRDM9
- EC
- 2.1.1.43
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 12 · 2 records with a druggable one
Structures
11 records of Q9NQV7 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4IJD | Crystal structure of methyltransferase domain of human PR domain-containing protein 9 | x-ray diffraction | A, B | — | — |
| 4IJD | Crystal structure of methyltransferase domain of human pr domain- containing protein 9 | x-ray diffraction | A, B | — | — |
| 5EGB | Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence II | x-ray diffraction | A | ZN | — |
| 5EGB | Human PRDM9 allele-a znf domain with associated recombination hotspot DNA sequence II | x-ray diffraction | A | — | — |
| 5EH2 | Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence III | x-ray diffraction | E, F | ZN | — |
| 5EH2 | Human PRDM9 allele-a znf domain with associated recombination hotspot DNA sequence III | x-ray diffraction | E, F | — | — |
| 5EI9 | Human PRDM9 allele-A ZnF Domain with Associated Recombination Hotspot DNA Sequence I | x-ray diffraction | F, E | ZN | — |
| 5EI9 | Human PRDM9 allele-a znf domain with associated recombination hotspot DNA sequence I | x-ray diffraction | F, E | — | — |
| 6NM4 | Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor | x-ray diffraction | A, B | ZN, SAM, KS7, UNX | 6 (best 0.60) |
| 6NM4 | Crystal structure of SAM-bound PRDM9 in complex with mrk-740 inhibitor | x-ray diffraction | A, B | ZN, KS7, UNX | — |
| Q9NQV7 | AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase PRDM9 (Q9NQV7) | predicted | A | — | 6 (best 0.54) |
Ligands
Experiment against prediction
- 4IJD chain B against the predicted model Q9NQV7: TM-score 0.99, RMSD 0.44 Å
- 4IJD chain B against the predicted model Q9NQV7: TM-score 0.99, RMSD 0.44 Å
- 6NM4 chain B against the predicted model Q9NQV7: TM-score 0.99, RMSD 0.60 Å
- 6NM4 chain A against the predicted model Q9NQV7: TM-score 0.98, RMSD 0.70 Å
- 6NM4 chain B against the predicted model Q9NQV7: TM-score 0.98, RMSD 0.60 Å
- 4IJD chain A against the predicted model Q9NQV7: TM-score 0.98, RMSD 0.86 Å
- 4IJD chain A against the predicted model Q9NQV7: TM-score 0.98, RMSD 0.86 Å
- 6NM4 chain A against the predicted model Q9NQV7: TM-score 0.98, RMSD 0.70 Å
- 5EI9 chain F against the predicted model Q9NQV7: TM-score 0.87, RMSD 1.56 Å
- 5EI9 chain F against the predicted model Q9NQV7: TM-score 0.87, RMSD 1.56 Å
Elsewhere
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