UniProt Q9NPF7
Interleukin-23 subunit alpha (Q9NPF7)
Interleukin-23 subunit alpha (UniProt Q9NPF7): 24 experimental structures and 1 predicted model on GenesisL1, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NPF7
- Protein
- Interleukin-23 subunit alpha
- Experimental structures
- 24
- Predicted models
- 1
- Pockets
- 12 · 4 records with a druggable one
Structures
25 records of Q9NPF7 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3D85 | Crystal structure of IL-23 in complex with neutralizing FAB | x-ray diffraction | C | — | — |
| 3D85 | Crystal structure of il-23 in complex with neutralizing Fab | x-ray diffraction | C | — | — |
| 3D87 | Crystal structure of Interleukin-23 | x-ray diffraction | A, C | — | — |
| 3D87 | Crystal structure of interleukin-23 | x-ray diffraction | A, C | — | — |
| 3DUH | Structure of Interleukin-23 | x-ray diffraction | C, D | — | — |
| 3DUH | Structure of interleukin-23 | x-ray diffraction | C, D | — | — |
| 3QWR | Crystal structure of IL-23 in complex with an adnectin | x-ray diffraction | B | — | — |
| 3QWR | Crystal structure of il-23 in complex with an adnectin | x-ray diffraction | B | — | — |
| 4GRW | Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) | x-ray diffraction | A, C | — | — |
| 4GRW | Structure of a complex of human il-23 with 3 nanobodies (llama vhhs) | x-ray diffraction | A, C | — | — |
| 5MJ3 | Interleukin-23 complex with an antagonistic alphabody, crystal form 1 | x-ray diffraction | B | — | 3 (best 0.74) |
| 5MJ3 | Interleukin-23 complex with an antagonistic alphabody, crystal form 1 | x-ray diffraction | B | — | — |
| 5MJ4 | Interleukin-23 complex with an antagonistic alphabody, crystal form 2 | x-ray diffraction | B | — | 2 (best 0.74) |
| 5MJ4 | Interleukin-23 complex with an antagonistic alphabody, crystal form 2 | x-ray diffraction | B | — | — |
| 5MXA | Structure of unbound Interleukin-23 | x-ray diffraction | B | — | — |
| 5MXA | Structure of unbound interleukin-23 | x-ray diffraction | B | — | — |
| 5MZV | IL-23:IL-23R:Nb22E11 complex | x-ray diffraction | B | — | — |
| 5MZV | Il-23:IL-23R:NB22E11 complex | x-ray diffraction | B | — | — |
| 5NJD | Structure of Interleukin 23 in complex with Briakinumab FAb | x-ray diffraction | B, D, F, H, J, L | — | — |
| 5NJD | Structure of interleukin 23 in complex with briakinumab Fab | x-ray diffraction | B, D, F, H, J, L | — | — |
| 6UIB | Crystal structure of IL23 bound to peptide 23-652 | x-ray diffraction | A | — | — |
| 6WDQ | IL23/IL23R/IL12Rb1 signaling complex | x-ray diffraction | B | — | 3 (best 0.83) |
| 6WDQ | IL23/IL23R/IL12RB1 signaling complex | x-ray diffraction | B | — | — |
| 8OE4 | Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. | electron microscopy | B | — | 4 (best 0.80) |
| Q9NPF7 | AlphaFold monomer V2.0 prediction for interleukin-23 subunit alpha (Q9NPF7) | predicted | A | — | — |
Experiment against prediction
- 4GRW chain C against the predicted model Q9NPF7: TM-score 0.97, RMSD 0.97 Å
- 4GRW chain C against the predicted model Q9NPF7: TM-score 0.97, RMSD 0.97 Å
- 4GRW chain A against the predicted model Q9NPF7: TM-score 0.95, RMSD 1.16 Å
- 4GRW chain A against the predicted model Q9NPF7: TM-score 0.95, RMSD 1.16 Å
- 3D85 chain C against the predicted model Q9NPF7: TM-score 0.95, RMSD 1.25 Å
- 3D85 chain C against the predicted model Q9NPF7: TM-score 0.95, RMSD 1.25 Å
- 6UIB chain A against the predicted model Q9NPF7: TM-score 0.95, RMSD 1.37 Å
- 8OE4 chain B against the predicted model Q9NPF7: TM-score 0.95, RMSD 1.18 Å
- 5MZV chain B against the predicted model Q9NPF7: TM-score 0.95, RMSD 1.41 Å
- 5MZV chain B against the predicted model Q9NPF7: TM-score 0.95, RMSD 1.41 Å
Elsewhere
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