UniProt Q9JLV6
Bifunctional polynucleotide phosphatase/kinase (Q9JLV6)
Bifunctional polynucleotide phosphatase/kinase (UniProt Q9JLV6), EC 2.7.1.78, 3.1.3.32: 20 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 116 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9JLV6
- Protein
- Bifunctional polynucleotide phosphatase/kinase
- EC
- 2.7.1.78, 3.1.3.32
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 116 · 19 records with a druggable one
Structures
21 records of Q9JLV6 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UJX | The forkhead associated (FHA) domain like structure from mouse polynucleotide kinase 3'-phosphatase | solution nmr | A | — | — |
| 1UJX | The forkhead associated (fha) domain like structure from mouse polynucleotide kinase 3'-phosphatase | solution nmr | A | — | — |
| 1YJ5 | Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme | x-ray diffraction | A, B, C | SO4 | 12 (best 0.76) |
| 1YJ5 | Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme | x-ray diffraction | A, B, C | SO4 | 12 (best 0.76) |
| 1YJM | Crystal structure of the FHA domain of mouse polynucleotide kinase in complex with an XRCC4-derived… | x-ray diffraction | A, B, C | — | 3 (best 0.57) |
| 1YJM | Crystal structure of the fha domain of mouse polynucleotide kinase in complex with an XRCC4-derived… | x-ray diffraction | A, B, C | ACE | 3 (best 0.57) |
| 3U7E | Crystal structure of mPNKP catalytic fragment (D170A) | x-ray diffraction | B | PO4, MG | 5 (best 0.67) |
| 3U7E | Crystal structure of mpnkp catalytic fragment (D170A) | x-ray diffraction | B | PO4, MG | 5 (best 0.67) |
| 3U7F | Crystal structure of mPNKP catalytic fragment (D170A) bound to single-stranded DNA (TCCTCp) | x-ray diffraction | B | MG, PO4 | 5 (best 0.66) |
| 3U7F | Crystal structure of mpnkp catalytic fragment (D170A) bound to single- stranded DNA (tcctcp) | x-ray diffraction | B | MG, PO4 | 5 (best 0.66) |
| 3U7G | Crystal structure of mPNKP catalytic fragment (D170A) bound to single-stranded DNA (TCCTAp) | x-ray diffraction | A | PO4, MG | 6 (best 0.60) |
| 3U7G | Crystal structure of mpnkp catalytic fragment (D170A) bound to single- stranded DNA (tcctap) | x-ray diffraction | A | PO4, MG | 6 (best 0.60) |
| 3U7H | Crystal structure of mPNKP catalytic fragment (D170A) bound to single-stranded DNA (TCCTTp) | x-ray diffraction | B | MG, PO4 | 5 (best 0.63) |
| 3U7H | Crystal structure of mpnkp catalytic fragment (D170A) bound to single- stranded DNA (tccttp) | x-ray diffraction | B | MG, PO4 | 5 (best 0.63) |
| 3ZVL | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | x-ray diffraction | A | MG, CL | 5 (best 0.65) |
| 3ZVL | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | x-ray diffraction | A | MG, CL | 5 (best 0.65) |
| 3ZVM | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | x-ray diffraction | A, B | ADP, MG | 11 (best 0.70) |
| 3ZVM | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | x-ray diffraction | A, B | ADP, MG | 11 (best 0.70) |
| 3ZVN | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | x-ray diffraction | A | MN, ADP | 4 (best 0.67) |
| 3ZVN | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | x-ray diffraction | A | MN, ADP | 4 (best 0.67) |
| Q9JLV6 | AlphaFold monomer V2.0 prediction for bifunctional polynucleotide PHOSPHATASE/KINASE (Q9JLV6) | predicted | A | — | 4 (best 0.72) |
Ligands
Experiment against prediction
- 1YJM chain C against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.33 Å
- 1YJM chain C against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.33 Å
- 1YJ5 chain B against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.70 Å
- 1YJ5 chain B against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.70 Å
- 3U7H chain B against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.71 Å
- 3U7H chain B against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.71 Å
- 3ZVL chain A against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.90 Å
- 3ZVL chain A against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.90 Å
- 3U7F chain B against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.82 Å
- 3U7F chain B against the predicted model Q9JLV6: TM-score 0.99, RMSD 0.82 Å
Elsewhere
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